Lentivirus-mediated silencing of the PTC1 and PTC2 genes promotes recovery from spinal cord injury by activating the Hedgehog signaling pathway in a rat model

This study aimed to investigate the effect of Patched-1 (PTC1) and PTC2 silencing in a rat model, on Hedgehog (Hh) pathway-mediated recovery from spinal cord injury (SCI). An analytical emphasis on the relationship between the sonic hedgehog (Shh) pathway and nerve regeneration was explored. A total...

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Detalles Bibliográficos
Autores principales: Zhang, Ya-Dong, Zhu, Zhong-Sheng, Zhang, Dong, Zhang, Zhen, Ma, Bin, Zhao, Shi-Chang, Xue, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750477/
https://www.ncbi.nlm.nih.gov/pubmed/29244790
http://dx.doi.org/10.1038/emm.2017.220

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