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Reduced sB7-H3 Expression in the Peripheral Blood of Systemic Lupus Erythematosus Patients
Both membrane-bound and soluble forms of costimulatory molecules play important roles in immune-regulatory networks. B7-H3, a member of the B7 family, has been found with aberrant expression in tumors and infectious disease. However, the significance of sB7-H3 expression in systemic lupus erythemato...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750499/ https://www.ncbi.nlm.nih.gov/pubmed/29423417 http://dx.doi.org/10.1155/2017/5728512 |
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author | Sun, Jing Lai, Huijun Shen, Dong Wu, Pingping Yang, Jie Sun, Zhongwen Guo, Yundi |
author_facet | Sun, Jing Lai, Huijun Shen, Dong Wu, Pingping Yang, Jie Sun, Zhongwen Guo, Yundi |
author_sort | Sun, Jing |
collection | PubMed |
description | Both membrane-bound and soluble forms of costimulatory molecules play important roles in immune-regulatory networks. B7-H3, a member of the B7 family, has been found with aberrant expression in tumors and infectious disease. However, the significance of sB7-H3 expression in systemic lupus erythematosus (SLE) has not been investigated. Using the peripheral blood of 78 SLE patients, we established a comprehensive database containing clinical data and relevant laboratory tests. We found that sB7-H3 expression in SLE patients was significantly lower compared with the healthy individuals. In addition, sB7-H3 levels in the patients were positively correlated with the disease activity as indicated by SLE disease activity index score, rashes, fever, and inflammatory cytokines. Moreover, sB7-H3 was associated with the counts of red blood cells and hemoglobin. Our findings suggest that sB7-H3 might counteract the aberrant immune response and potentially serve as a monitoring indicator of disease progression and therapeutic target in SLE treatment. |
format | Online Article Text |
id | pubmed-5750499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-57504992018-02-08 Reduced sB7-H3 Expression in the Peripheral Blood of Systemic Lupus Erythematosus Patients Sun, Jing Lai, Huijun Shen, Dong Wu, Pingping Yang, Jie Sun, Zhongwen Guo, Yundi J Immunol Res Research Article Both membrane-bound and soluble forms of costimulatory molecules play important roles in immune-regulatory networks. B7-H3, a member of the B7 family, has been found with aberrant expression in tumors and infectious disease. However, the significance of sB7-H3 expression in systemic lupus erythematosus (SLE) has not been investigated. Using the peripheral blood of 78 SLE patients, we established a comprehensive database containing clinical data and relevant laboratory tests. We found that sB7-H3 expression in SLE patients was significantly lower compared with the healthy individuals. In addition, sB7-H3 levels in the patients were positively correlated with the disease activity as indicated by SLE disease activity index score, rashes, fever, and inflammatory cytokines. Moreover, sB7-H3 was associated with the counts of red blood cells and hemoglobin. Our findings suggest that sB7-H3 might counteract the aberrant immune response and potentially serve as a monitoring indicator of disease progression and therapeutic target in SLE treatment. Hindawi 2017 2017-12-20 /pmc/articles/PMC5750499/ /pubmed/29423417 http://dx.doi.org/10.1155/2017/5728512 Text en Copyright © 2017 Jing Sun et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Sun, Jing Lai, Huijun Shen, Dong Wu, Pingping Yang, Jie Sun, Zhongwen Guo, Yundi Reduced sB7-H3 Expression in the Peripheral Blood of Systemic Lupus Erythematosus Patients |
title | Reduced sB7-H3 Expression in the Peripheral Blood of Systemic Lupus Erythematosus Patients |
title_full | Reduced sB7-H3 Expression in the Peripheral Blood of Systemic Lupus Erythematosus Patients |
title_fullStr | Reduced sB7-H3 Expression in the Peripheral Blood of Systemic Lupus Erythematosus Patients |
title_full_unstemmed | Reduced sB7-H3 Expression in the Peripheral Blood of Systemic Lupus Erythematosus Patients |
title_short | Reduced sB7-H3 Expression in the Peripheral Blood of Systemic Lupus Erythematosus Patients |
title_sort | reduced sb7-h3 expression in the peripheral blood of systemic lupus erythematosus patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750499/ https://www.ncbi.nlm.nih.gov/pubmed/29423417 http://dx.doi.org/10.1155/2017/5728512 |
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