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Relationship between Bone Health Biomarkers and Cardiovascular Risk in a General Adult Population

Purpose/Introduction: Osteoporosis (OP) and cardiovascular (CV) disease emerge as closely related conditions, showing common risk factors and/or pathophysiological mechanisms. The aim of this study was to evaluate the association between bone health markers (BHM) and individual CV risk factors and o...

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Autores principales: Vassalle, Cristina, Sabatino, Laura, Di Cecco, Pietro, Maltinti, Maristella, Ndreu, Rudina, Maffei, Silvia, Pingitore, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750535/
https://www.ncbi.nlm.nih.gov/pubmed/29064392
http://dx.doi.org/10.3390/diseases5040024
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author Vassalle, Cristina
Sabatino, Laura
Di Cecco, Pietro
Maltinti, Maristella
Ndreu, Rudina
Maffei, Silvia
Pingitore, Alessandro
author_facet Vassalle, Cristina
Sabatino, Laura
Di Cecco, Pietro
Maltinti, Maristella
Ndreu, Rudina
Maffei, Silvia
Pingitore, Alessandro
author_sort Vassalle, Cristina
collection PubMed
description Purpose/Introduction: Osteoporosis (OP) and cardiovascular (CV) disease emerge as closely related conditions, showing common risk factors and/or pathophysiological mechanisms. The aim of this study was to evaluate the association between bone health markers (BHM) and individual CV risk factors and overall CV risk (FRAMINGHAM-FRS, and PROCAM scores) in a general adult population. Methods: In 103 subjects (21 males; age: 56 ± 12 years), vitamin D (25(OH)D), osteocalcin (OC), bone alkaline phospatase (BALP), procollagen I aminoterminal propeptide (P1NP), CTx-telopeptide, as well clinical history and life style were evaluated. Results: Aging (p < 0.001) and glycemia (p < 0.05) emerged as independent 25(OH)D predictors. Aging (p < 0.001), male sex (p < 0.05), and obesity (p < 0.05) represented independent OC determinants. Aging (p < 0.05) was the only independent BALP determinant. After multivariate adjustment, low 25(OH)D (<20 ng/mL) (Odds ratio OR (95% confidence intervals CI)) (5 (1.4–18) p < 0.05) and elevated OC (>75th percentile-16.6 ng/mL) (6.7 (1.9–23.8) p < 0.01) were found to be significant FRS predictors, while subjects with elevated OC and/or BALP (>75th percentile-9.8 μg/L) showed a higher CV risk as estimated by PROCAM (3.6 (1.2–10.7) p < 0.05). CTx and P1NP did not significantly correlate with CV risk factors or scores. Conclusion: As we go further into bone and CV physiology, it is evident that a close relationship exists between these diseases. Further studies are needed to investigate mechanisms by which bone turnover markers are related to metabolic risk and could modulate CV risk. This knowledge may help to develop possible multiple-purpose strategies for both CV disease and OP prevention and treatment.
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spelling pubmed-57505352018-01-08 Relationship between Bone Health Biomarkers and Cardiovascular Risk in a General Adult Population Vassalle, Cristina Sabatino, Laura Di Cecco, Pietro Maltinti, Maristella Ndreu, Rudina Maffei, Silvia Pingitore, Alessandro Diseases Article Purpose/Introduction: Osteoporosis (OP) and cardiovascular (CV) disease emerge as closely related conditions, showing common risk factors and/or pathophysiological mechanisms. The aim of this study was to evaluate the association between bone health markers (BHM) and individual CV risk factors and overall CV risk (FRAMINGHAM-FRS, and PROCAM scores) in a general adult population. Methods: In 103 subjects (21 males; age: 56 ± 12 years), vitamin D (25(OH)D), osteocalcin (OC), bone alkaline phospatase (BALP), procollagen I aminoterminal propeptide (P1NP), CTx-telopeptide, as well clinical history and life style were evaluated. Results: Aging (p < 0.001) and glycemia (p < 0.05) emerged as independent 25(OH)D predictors. Aging (p < 0.001), male sex (p < 0.05), and obesity (p < 0.05) represented independent OC determinants. Aging (p < 0.05) was the only independent BALP determinant. After multivariate adjustment, low 25(OH)D (<20 ng/mL) (Odds ratio OR (95% confidence intervals CI)) (5 (1.4–18) p < 0.05) and elevated OC (>75th percentile-16.6 ng/mL) (6.7 (1.9–23.8) p < 0.01) were found to be significant FRS predictors, while subjects with elevated OC and/or BALP (>75th percentile-9.8 μg/L) showed a higher CV risk as estimated by PROCAM (3.6 (1.2–10.7) p < 0.05). CTx and P1NP did not significantly correlate with CV risk factors or scores. Conclusion: As we go further into bone and CV physiology, it is evident that a close relationship exists between these diseases. Further studies are needed to investigate mechanisms by which bone turnover markers are related to metabolic risk and could modulate CV risk. This knowledge may help to develop possible multiple-purpose strategies for both CV disease and OP prevention and treatment. MDPI 2017-10-24 /pmc/articles/PMC5750535/ /pubmed/29064392 http://dx.doi.org/10.3390/diseases5040024 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vassalle, Cristina
Sabatino, Laura
Di Cecco, Pietro
Maltinti, Maristella
Ndreu, Rudina
Maffei, Silvia
Pingitore, Alessandro
Relationship between Bone Health Biomarkers and Cardiovascular Risk in a General Adult Population
title Relationship between Bone Health Biomarkers and Cardiovascular Risk in a General Adult Population
title_full Relationship between Bone Health Biomarkers and Cardiovascular Risk in a General Adult Population
title_fullStr Relationship between Bone Health Biomarkers and Cardiovascular Risk in a General Adult Population
title_full_unstemmed Relationship between Bone Health Biomarkers and Cardiovascular Risk in a General Adult Population
title_short Relationship between Bone Health Biomarkers and Cardiovascular Risk in a General Adult Population
title_sort relationship between bone health biomarkers and cardiovascular risk in a general adult population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750535/
https://www.ncbi.nlm.nih.gov/pubmed/29064392
http://dx.doi.org/10.3390/diseases5040024
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