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Tissue Specific Modulation of cyp2c and cyp3a mRNA Levels and Activities by Diet-Induced Obesity in Mice: The Impact of Type 2 Diabetes on Drug Metabolizing Enzymes in Liver and Extra-Hepatic Tissues

Various diseases such as type 2 diabetes (T2D) may alter drug clearance. The objective of this study was to evaluate the effects of T2D on CYP450 expressions and activities using high-fat diet (HFD) as a model of obesity-dependent diabetes in C57BL6 mice. The cyp450 mRNA expression levels for 15 dif...

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Detalles Bibliográficos
Autores principales:	Maximos, Sarah, Chamoun, Michel, Gravel, Sophie, Turgeon, Jacques, Michaud, Veronique
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750646/ https://www.ncbi.nlm.nih.gov/pubmed/28954402 http://dx.doi.org/10.3390/pharmaceutics9040040

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