Preparation and Characterization of Carbamazepine Cocrystal in Polymer Solution

In this study, we attempted to prepare carbamazepine (CBZ) cocrystal through the solution method in ethanol-water solvent mixture (volume ratio 1:1) and polyvinyl pyrrolidone (PVP) solution. Nicotinamide (NIC) and saccharin (SAC) were selected as cocrystal coformers. Cocrystal screening products wer...

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Detalles Bibliográficos
Autores principales: Zhang, Hao, Zhu, Ying, Qiao, Ning, Chen, Yang, Gao, Linghuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750660/
https://www.ncbi.nlm.nih.gov/pubmed/29194387
http://dx.doi.org/10.3390/pharmaceutics9040054
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author Zhang, Hao
Zhu, Ying
Qiao, Ning
Chen, Yang
Gao, Linghuan
author_facet Zhang, Hao
Zhu, Ying
Qiao, Ning
Chen, Yang
Gao, Linghuan
author_sort Zhang, Hao
collection PubMed
description In this study, we attempted to prepare carbamazepine (CBZ) cocrystal through the solution method in ethanol-water solvent mixture (volume ratio 1:1) and polyvinyl pyrrolidone (PVP) solution. Nicotinamide (NIC) and saccharin (SAC) were selected as cocrystal coformers. Cocrystal screening products were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), and Powder X-ray Diffraction (PXRD) techniques. Characterization results show that in ethanol-water solvent mixture, pure CBZ-NIC cocrystal can be prepared, while CBZ-SAC cocrystal cannot be obtained. The addition of PVP can inhibit CBZ-NIC cocrystal formation and facilitate CBZ-SAC cocrystal formation.
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spelling pubmed-57506602018-01-10 Preparation and Characterization of Carbamazepine Cocrystal in Polymer Solution Zhang, Hao Zhu, Ying Qiao, Ning Chen, Yang Gao, Linghuan Pharmaceutics Article In this study, we attempted to prepare carbamazepine (CBZ) cocrystal through the solution method in ethanol-water solvent mixture (volume ratio 1:1) and polyvinyl pyrrolidone (PVP) solution. Nicotinamide (NIC) and saccharin (SAC) were selected as cocrystal coformers. Cocrystal screening products were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), and Powder X-ray Diffraction (PXRD) techniques. Characterization results show that in ethanol-water solvent mixture, pure CBZ-NIC cocrystal can be prepared, while CBZ-SAC cocrystal cannot be obtained. The addition of PVP can inhibit CBZ-NIC cocrystal formation and facilitate CBZ-SAC cocrystal formation. MDPI 2017-12-01 /pmc/articles/PMC5750660/ /pubmed/29194387 http://dx.doi.org/10.3390/pharmaceutics9040054 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Hao
Zhu, Ying
Qiao, Ning
Chen, Yang
Gao, Linghuan
Preparation and Characterization of Carbamazepine Cocrystal in Polymer Solution
title Preparation and Characterization of Carbamazepine Cocrystal in Polymer Solution
title_full Preparation and Characterization of Carbamazepine Cocrystal in Polymer Solution
title_fullStr Preparation and Characterization of Carbamazepine Cocrystal in Polymer Solution
title_full_unstemmed Preparation and Characterization of Carbamazepine Cocrystal in Polymer Solution
title_short Preparation and Characterization of Carbamazepine Cocrystal in Polymer Solution
title_sort preparation and characterization of carbamazepine cocrystal in polymer solution
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750660/
https://www.ncbi.nlm.nih.gov/pubmed/29194387
http://dx.doi.org/10.3390/pharmaceutics9040054
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AT zhuying preparationandcharacterizationofcarbamazepinecocrystalinpolymersolution
AT qiaoning preparationandcharacterizationofcarbamazepinecocrystalinpolymersolution
AT chenyang preparationandcharacterizationofcarbamazepinecocrystalinpolymersolution
AT gaolinghuan preparationandcharacterizationofcarbamazepinecocrystalinpolymersolution

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