The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint

Engagement of programmed death-ligand 1 (PD-L1) with its receptor programmed death 1 (PD-1) on T cells has been speculated to play a major role in suppressing the immune system, which helps tumor cells evade anti-tumor immunity. With the development of whole genome sequencing technologies, microRNAs...

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Detalles Bibliográficos
Autores principales: Wang, Qingshui, Lin, Wei, Tang, Xiaoqiong, Li, Suhuan, Guo, Libin, Lin, Yao, Kwok, Hang Fai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751143/
https://www.ncbi.nlm.nih.gov/pubmed/29186904
http://dx.doi.org/10.3390/ijms18122540
Descripción
Sumario:Engagement of programmed death-ligand 1 (PD-L1) with its receptor programmed death 1 (PD-1) on T cells has been speculated to play a major role in suppressing the immune system, which helps tumor cells evade anti-tumor immunity. With the development of whole genome sequencing technologies, microRNAs have gained more attention as an important new layer of molecular regulation. Recent studies have revealed that altered expression of microRNAs play a pivotal role in immune checkpoint and various cellular processes in cancer. In this review, we focused on the latest progress about microRNAs research which involves the regulation of PD-1/PD-L1 immune checkpoint.

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