The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint

Engagement of programmed death-ligand 1 (PD-L1) with its receptor programmed death 1 (PD-1) on T cells has been speculated to play a major role in suppressing the immune system, which helps tumor cells evade anti-tumor immunity. With the development of whole genome sequencing technologies, microRNAs...

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Detalles Bibliográficos
Autores principales: Wang, Qingshui, Lin, Wei, Tang, Xiaoqiong, Li, Suhuan, Guo, Libin, Lin, Yao, Kwok, Hang Fai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751143/
https://www.ncbi.nlm.nih.gov/pubmed/29186904
http://dx.doi.org/10.3390/ijms18122540
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author Wang, Qingshui
Lin, Wei
Tang, Xiaoqiong
Li, Suhuan
Guo, Libin
Lin, Yao
Kwok, Hang Fai
author_facet Wang, Qingshui
Lin, Wei
Tang, Xiaoqiong
Li, Suhuan
Guo, Libin
Lin, Yao
Kwok, Hang Fai
author_sort Wang, Qingshui
collection PubMed
description Engagement of programmed death-ligand 1 (PD-L1) with its receptor programmed death 1 (PD-1) on T cells has been speculated to play a major role in suppressing the immune system, which helps tumor cells evade anti-tumor immunity. With the development of whole genome sequencing technologies, microRNAs have gained more attention as an important new layer of molecular regulation. Recent studies have revealed that altered expression of microRNAs play a pivotal role in immune checkpoint and various cellular processes in cancer. In this review, we focused on the latest progress about microRNAs research which involves the regulation of PD-1/PD-L1 immune checkpoint.
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spelling pubmed-57511432018-01-08 The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint Wang, Qingshui Lin, Wei Tang, Xiaoqiong Li, Suhuan Guo, Libin Lin, Yao Kwok, Hang Fai Int J Mol Sci Review Engagement of programmed death-ligand 1 (PD-L1) with its receptor programmed death 1 (PD-1) on T cells has been speculated to play a major role in suppressing the immune system, which helps tumor cells evade anti-tumor immunity. With the development of whole genome sequencing technologies, microRNAs have gained more attention as an important new layer of molecular regulation. Recent studies have revealed that altered expression of microRNAs play a pivotal role in immune checkpoint and various cellular processes in cancer. In this review, we focused on the latest progress about microRNAs research which involves the regulation of PD-1/PD-L1 immune checkpoint. MDPI 2017-11-27 /pmc/articles/PMC5751143/ /pubmed/29186904 http://dx.doi.org/10.3390/ijms18122540 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Qingshui
Lin, Wei
Tang, Xiaoqiong
Li, Suhuan
Guo, Libin
Lin, Yao
Kwok, Hang Fai
The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint
title The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint
title_full The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint
title_fullStr The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint
title_full_unstemmed The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint
title_short The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint
title_sort roles of micrornas in regulating the expression of pd-1/pd-l1 immune checkpoint
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751143/
https://www.ncbi.nlm.nih.gov/pubmed/29186904
http://dx.doi.org/10.3390/ijms18122540
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