Insights into Insulin Fibril Assembly at Physiological and Acidic pH and Related Amyloid Intrinsic Fluorescence

Human insulin is a widely used model protein for the study of amyloid formation as both associated to insulin injection amyloidosis in type II diabetes and highly prone to form amyloid fibrils in vitro. In this study, we aim to gain new structural insights into insulin fibril formation under two dif...

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Detalles Bibliográficos
Autores principales: Iannuzzi, Clara, Borriello, Margherita, Portaccio, Marianna, Irace, Gaetano, Sirangelo, Ivana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751154/
https://www.ncbi.nlm.nih.gov/pubmed/29182566
http://dx.doi.org/10.3390/ijms18122551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751154/
https://www.ncbi.nlm.nih.gov/pubmed/29182566
http://dx.doi.org/10.3390/ijms18122551

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