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Telomeres, Aging and Exercise: Guilty by Association?
Telomeres are repetitive tandem DNA sequences that cap chromosomal ends protecting genomic DNA from enzymatic degradation. Telomeres progressively shorten with cellular replication and are therefore assumed to correlate with biological and chronological age. An expanding body of evidence suggests (i...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751176/ https://www.ncbi.nlm.nih.gov/pubmed/29186077 http://dx.doi.org/10.3390/ijms18122573 |
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author | Chilton, Warrick O’Brien, Brendan Charchar, Fadi |
author_facet | Chilton, Warrick O’Brien, Brendan Charchar, Fadi |
author_sort | Chilton, Warrick |
collection | PubMed |
description | Telomeres are repetitive tandem DNA sequences that cap chromosomal ends protecting genomic DNA from enzymatic degradation. Telomeres progressively shorten with cellular replication and are therefore assumed to correlate with biological and chronological age. An expanding body of evidence suggests (i) a predictable inverse association between telomere length, aging and age-related diseases and (ii) a positive association between physical activity and telomere length. Both hypotheses have garnered tremendous research attention and broad consensus; however, the evidence for each proposition is inconsistent and equivocal at best. Telomere length does not meet the basic criteria for an aging biomarker and at least 50% of key studies fail to find associations with physical activity. In this review, we address the evidence in support and refutation of the putative associations between telomere length, aging and physical activity. We finish with a brief review of plausible mechanisms and potential future research directions. |
format | Online Article Text |
id | pubmed-5751176 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57511762018-01-08 Telomeres, Aging and Exercise: Guilty by Association? Chilton, Warrick O’Brien, Brendan Charchar, Fadi Int J Mol Sci Review Telomeres are repetitive tandem DNA sequences that cap chromosomal ends protecting genomic DNA from enzymatic degradation. Telomeres progressively shorten with cellular replication and are therefore assumed to correlate with biological and chronological age. An expanding body of evidence suggests (i) a predictable inverse association between telomere length, aging and age-related diseases and (ii) a positive association between physical activity and telomere length. Both hypotheses have garnered tremendous research attention and broad consensus; however, the evidence for each proposition is inconsistent and equivocal at best. Telomere length does not meet the basic criteria for an aging biomarker and at least 50% of key studies fail to find associations with physical activity. In this review, we address the evidence in support and refutation of the putative associations between telomere length, aging and physical activity. We finish with a brief review of plausible mechanisms and potential future research directions. MDPI 2017-11-29 /pmc/articles/PMC5751176/ /pubmed/29186077 http://dx.doi.org/10.3390/ijms18122573 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chilton, Warrick O’Brien, Brendan Charchar, Fadi Telomeres, Aging and Exercise: Guilty by Association? |
title | Telomeres, Aging and Exercise: Guilty by Association? |
title_full | Telomeres, Aging and Exercise: Guilty by Association? |
title_fullStr | Telomeres, Aging and Exercise: Guilty by Association? |
title_full_unstemmed | Telomeres, Aging and Exercise: Guilty by Association? |
title_short | Telomeres, Aging and Exercise: Guilty by Association? |
title_sort | telomeres, aging and exercise: guilty by association? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751176/ https://www.ncbi.nlm.nih.gov/pubmed/29186077 http://dx.doi.org/10.3390/ijms18122573 |
work_keys_str_mv | AT chiltonwarrick telomeresagingandexerciseguiltybyassociation AT obrienbrendan telomeresagingandexerciseguiltybyassociation AT charcharfadi telomeresagingandexerciseguiltybyassociation |