Glucocorticoids Improve Myogenic Differentiation In Vitro by Suppressing the Synthesis of Versican, a Transitional Matrix Protein Overexpressed in Dystrophic Skeletal Muscles

In Duchenne muscular dystrophy (DMD), a dysregulated extracellular matrix (ECM) directly exacerbates pathology. Glucocorticoids are beneficial therapeutics in DMD, and have pleiotropic effects on the composition and processing of ECM proteins in other biological contexts. The synthesis and remodelli...

Descripción completa

Detalles Bibliográficos
Autores principales: McRae, Natasha, Forgan, Leonard, McNeill, Bryony, Addinsall, Alex, McCulloch, Daniel, Van der Poel, Chris, Stupka, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751232/
https://www.ncbi.nlm.nih.gov/pubmed/29211034
http://dx.doi.org/10.3390/ijms18122629

Ejemplares similares

Ejemplares similares