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The Immunogenetics of Psoriasis and Implications for Drug Repositioning

Psoriasis is a genetically-regulated, T lymphocyte-mediated autoimmune skin disease that causes systemic damage, seriously affecting patient quality of life and survival. Psoriasis treatments, which aim to control the disease’s development, are greatly limited because its etiology and pathogenesis h...

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Detalles Bibliográficos
Autores principales: Xu, Xuan, Zhang, Hong-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751252/
https://www.ncbi.nlm.nih.gov/pubmed/29292715
http://dx.doi.org/10.3390/ijms18122650
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author Xu, Xuan
Zhang, Hong-Yu
author_facet Xu, Xuan
Zhang, Hong-Yu
author_sort Xu, Xuan
collection PubMed
description Psoriasis is a genetically-regulated, T lymphocyte-mediated autoimmune skin disease that causes systemic damage, seriously affecting patient quality of life and survival. Psoriasis treatments, which aim to control the disease’s development, are greatly limited because its etiology and pathogenesis have not yet been fully elucidated. A large number of studies have demonstrated that immunogenetic elements are the most important factors responsible for psoriasis susceptibility. This paper delineates the immunogenetic mechanisms of psoriasis and provides useful information with regards to performing drug repositioning for the treatment of psoriasis.
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spelling pubmed-57512522018-01-08 The Immunogenetics of Psoriasis and Implications for Drug Repositioning Xu, Xuan Zhang, Hong-Yu Int J Mol Sci Review Psoriasis is a genetically-regulated, T lymphocyte-mediated autoimmune skin disease that causes systemic damage, seriously affecting patient quality of life and survival. Psoriasis treatments, which aim to control the disease’s development, are greatly limited because its etiology and pathogenesis have not yet been fully elucidated. A large number of studies have demonstrated that immunogenetic elements are the most important factors responsible for psoriasis susceptibility. This paper delineates the immunogenetic mechanisms of psoriasis and provides useful information with regards to performing drug repositioning for the treatment of psoriasis. MDPI 2017-12-08 /pmc/articles/PMC5751252/ /pubmed/29292715 http://dx.doi.org/10.3390/ijms18122650 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Xu, Xuan
Zhang, Hong-Yu
The Immunogenetics of Psoriasis and Implications for Drug Repositioning
title The Immunogenetics of Psoriasis and Implications for Drug Repositioning
title_full The Immunogenetics of Psoriasis and Implications for Drug Repositioning
title_fullStr The Immunogenetics of Psoriasis and Implications for Drug Repositioning
title_full_unstemmed The Immunogenetics of Psoriasis and Implications for Drug Repositioning
title_short The Immunogenetics of Psoriasis and Implications for Drug Repositioning
title_sort immunogenetics of psoriasis and implications for drug repositioning
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751252/
https://www.ncbi.nlm.nih.gov/pubmed/29292715
http://dx.doi.org/10.3390/ijms18122650
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