Cargando…
The Immunogenetics of Psoriasis and Implications for Drug Repositioning
Psoriasis is a genetically-regulated, T lymphocyte-mediated autoimmune skin disease that causes systemic damage, seriously affecting patient quality of life and survival. Psoriasis treatments, which aim to control the disease’s development, are greatly limited because its etiology and pathogenesis h...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751252/ https://www.ncbi.nlm.nih.gov/pubmed/29292715 http://dx.doi.org/10.3390/ijms18122650 |
_version_ | 1783289908378468352 |
---|---|
author | Xu, Xuan Zhang, Hong-Yu |
author_facet | Xu, Xuan Zhang, Hong-Yu |
author_sort | Xu, Xuan |
collection | PubMed |
description | Psoriasis is a genetically-regulated, T lymphocyte-mediated autoimmune skin disease that causes systemic damage, seriously affecting patient quality of life and survival. Psoriasis treatments, which aim to control the disease’s development, are greatly limited because its etiology and pathogenesis have not yet been fully elucidated. A large number of studies have demonstrated that immunogenetic elements are the most important factors responsible for psoriasis susceptibility. This paper delineates the immunogenetic mechanisms of psoriasis and provides useful information with regards to performing drug repositioning for the treatment of psoriasis. |
format | Online Article Text |
id | pubmed-5751252 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57512522018-01-08 The Immunogenetics of Psoriasis and Implications for Drug Repositioning Xu, Xuan Zhang, Hong-Yu Int J Mol Sci Review Psoriasis is a genetically-regulated, T lymphocyte-mediated autoimmune skin disease that causes systemic damage, seriously affecting patient quality of life and survival. Psoriasis treatments, which aim to control the disease’s development, are greatly limited because its etiology and pathogenesis have not yet been fully elucidated. A large number of studies have demonstrated that immunogenetic elements are the most important factors responsible for psoriasis susceptibility. This paper delineates the immunogenetic mechanisms of psoriasis and provides useful information with regards to performing drug repositioning for the treatment of psoriasis. MDPI 2017-12-08 /pmc/articles/PMC5751252/ /pubmed/29292715 http://dx.doi.org/10.3390/ijms18122650 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Xu, Xuan Zhang, Hong-Yu The Immunogenetics of Psoriasis and Implications for Drug Repositioning |
title | The Immunogenetics of Psoriasis and Implications for Drug Repositioning |
title_full | The Immunogenetics of Psoriasis and Implications for Drug Repositioning |
title_fullStr | The Immunogenetics of Psoriasis and Implications for Drug Repositioning |
title_full_unstemmed | The Immunogenetics of Psoriasis and Implications for Drug Repositioning |
title_short | The Immunogenetics of Psoriasis and Implications for Drug Repositioning |
title_sort | immunogenetics of psoriasis and implications for drug repositioning |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751252/ https://www.ncbi.nlm.nih.gov/pubmed/29292715 http://dx.doi.org/10.3390/ijms18122650 |
work_keys_str_mv | AT xuxuan theimmunogeneticsofpsoriasisandimplicationsfordrugrepositioning AT zhanghongyu theimmunogeneticsofpsoriasisandimplicationsfordrugrepositioning AT xuxuan immunogeneticsofpsoriasisandimplicationsfordrugrepositioning AT zhanghongyu immunogeneticsofpsoriasisandimplicationsfordrugrepositioning |