RSV Infection in Human Macrophages Promotes CXCL10/IP-10 Expression during Bacterial Co-Infection

Respiratory syncytial virus (RSV), a major etiologic agent of acute lower respiratory infection constitutes the most important cause of death in young children worldwide. Viral/bacterial mixed infections are related to severity of respiratory inflammatory diseases, but the underlying mechanisms rema...

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Detalles Bibliográficos
Autores principales: Machado, Daniela, Hoffmann, Jonathan, Moroso, Marie, Rosa-Calatrava, Manuel, Endtz, Hubert, Terrier, Olivier, Paranhos-Baccalà, Glaucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751256/
https://www.ncbi.nlm.nih.gov/pubmed/29215596
http://dx.doi.org/10.3390/ijms18122654
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author Machado, Daniela
Hoffmann, Jonathan
Moroso, Marie
Rosa-Calatrava, Manuel
Endtz, Hubert
Terrier, Olivier
Paranhos-Baccalà, Glaucia
author_facet Machado, Daniela
Hoffmann, Jonathan
Moroso, Marie
Rosa-Calatrava, Manuel
Endtz, Hubert
Terrier, Olivier
Paranhos-Baccalà, Glaucia
author_sort Machado, Daniela
collection PubMed
description Respiratory syncytial virus (RSV), a major etiologic agent of acute lower respiratory infection constitutes the most important cause of death in young children worldwide. Viral/bacterial mixed infections are related to severity of respiratory inflammatory diseases, but the underlying mechanisms remain poorly understood. We have previously investigated the intracellular mechanisms that mediate the immune response in the context of influenza virus/Streptococcus pneumoniae (Sp) co-infection using a model of human monocyte-derived macrophages (MDMs). Here, we set up and characterized a similar model of MDMs to investigate different scenarios of RSV infection and co-infection with Sp. Our results suggest that Sp contributes to a faster and possibly higher level of CXCL10/IP-10 expression induced by RSV infection in human MDMs.
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spelling pubmed-57512562018-01-08 RSV Infection in Human Macrophages Promotes CXCL10/IP-10 Expression during Bacterial Co-Infection Machado, Daniela Hoffmann, Jonathan Moroso, Marie Rosa-Calatrava, Manuel Endtz, Hubert Terrier, Olivier Paranhos-Baccalà, Glaucia Int J Mol Sci Communication Respiratory syncytial virus (RSV), a major etiologic agent of acute lower respiratory infection constitutes the most important cause of death in young children worldwide. Viral/bacterial mixed infections are related to severity of respiratory inflammatory diseases, but the underlying mechanisms remain poorly understood. We have previously investigated the intracellular mechanisms that mediate the immune response in the context of influenza virus/Streptococcus pneumoniae (Sp) co-infection using a model of human monocyte-derived macrophages (MDMs). Here, we set up and characterized a similar model of MDMs to investigate different scenarios of RSV infection and co-infection with Sp. Our results suggest that Sp contributes to a faster and possibly higher level of CXCL10/IP-10 expression induced by RSV infection in human MDMs. MDPI 2017-12-07 /pmc/articles/PMC5751256/ /pubmed/29215596 http://dx.doi.org/10.3390/ijms18122654 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Machado, Daniela
Hoffmann, Jonathan
Moroso, Marie
Rosa-Calatrava, Manuel
Endtz, Hubert
Terrier, Olivier
Paranhos-Baccalà, Glaucia
RSV Infection in Human Macrophages Promotes CXCL10/IP-10 Expression during Bacterial Co-Infection
title RSV Infection in Human Macrophages Promotes CXCL10/IP-10 Expression during Bacterial Co-Infection
title_full RSV Infection in Human Macrophages Promotes CXCL10/IP-10 Expression during Bacterial Co-Infection
title_fullStr RSV Infection in Human Macrophages Promotes CXCL10/IP-10 Expression during Bacterial Co-Infection
title_full_unstemmed RSV Infection in Human Macrophages Promotes CXCL10/IP-10 Expression during Bacterial Co-Infection
title_short RSV Infection in Human Macrophages Promotes CXCL10/IP-10 Expression during Bacterial Co-Infection
title_sort rsv infection in human macrophages promotes cxcl10/ip-10 expression during bacterial co-infection
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751256/
https://www.ncbi.nlm.nih.gov/pubmed/29215596
http://dx.doi.org/10.3390/ijms18122654
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