Galectin-1 Inhibitor OTX008 Induces Tumor Vessel Normalization and Tumor Growth Inhibition in Human Head and Neck Squamous Cell Carcinoma Models

Galectin-1 is a hypoxia-regulated protein and a prognostic marker in head and neck squamous cell carcinomas (HNSCC). Here we assessed the ability of non-peptidic galectin-1 inhibitor OTX008 to improve tumor oxygenation levels via tumor vessel normalization as well as tumor growth inhibition in two h...

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Detalles Bibliográficos
Autores principales: Koonce, Nathan A., Griffin, Robert J., Dings, Ruud P. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751273/
https://www.ncbi.nlm.nih.gov/pubmed/29232825
http://dx.doi.org/10.3390/ijms18122671

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751273/
https://www.ncbi.nlm.nih.gov/pubmed/29232825
http://dx.doi.org/10.3390/ijms18122671

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