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Synthesis and Characterization of Nanofunctionalized Gelatin Methacrylate Hydrogels
Given the importance of the extracellular medium during tissue formation, it was wise to develop an artificial structure that mimics the extracellular matrix while having improved physico-chemical properties. That is why the choice was focused on gelatin methacryloyl (GelMA), an inexpensive biocompa...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751277/ https://www.ncbi.nlm.nih.gov/pubmed/29232870 http://dx.doi.org/10.3390/ijms18122675 |
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author | Rahali, Kamel Ben Messaoud, Ghazi Kahn, Cyril J.F. Sanchez-Gonzalez, Laura Kaci, Mouna Cleymand, Franck Fleutot, Solenne Linder, Michel Desobry, Stéphane Arab-Tehrany, Elmira |
author_facet | Rahali, Kamel Ben Messaoud, Ghazi Kahn, Cyril J.F. Sanchez-Gonzalez, Laura Kaci, Mouna Cleymand, Franck Fleutot, Solenne Linder, Michel Desobry, Stéphane Arab-Tehrany, Elmira |
author_sort | Rahali, Kamel |
collection | PubMed |
description | Given the importance of the extracellular medium during tissue formation, it was wise to develop an artificial structure that mimics the extracellular matrix while having improved physico-chemical properties. That is why the choice was focused on gelatin methacryloyl (GelMA), an inexpensive biocompatible hydrogel. Physicochemical and mechanical properties were improved by the incorporation of nanoparticles developed from two innovative fabrication processes: High shear fluid and low frequencies/high frequencies ultrasounds. Both rapeseed nanoliposomes and nanodroplets were successfully incorporated in the GelMA networks during the photo polymerization process. The impact on polymer microstructure was investigated by Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and enzymatic degradation investigations. Mechanical stability and viscoelastic tests were conducted to demonstrate the beneficial effect of the functionalization on GelMA hydrogels. Adding nanoparticles to GelMA improved the surface properties (porosity), tuned swelling, and degradability properties. In addition, we observed that nanoemulsion didn’t change significantly the mechanical properties to shear and compression solicitations, whereas nanoliposome addition decreased Young’s modulus under compression solicitations. Thus, these ways of functionalization allow controlling the design of the material by choosing the type of nanoparticle (nanoliposome or nanoemulsion) in function of the application. |
format | Online Article Text |
id | pubmed-5751277 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57512772018-01-08 Synthesis and Characterization of Nanofunctionalized Gelatin Methacrylate Hydrogels Rahali, Kamel Ben Messaoud, Ghazi Kahn, Cyril J.F. Sanchez-Gonzalez, Laura Kaci, Mouna Cleymand, Franck Fleutot, Solenne Linder, Michel Desobry, Stéphane Arab-Tehrany, Elmira Int J Mol Sci Article Given the importance of the extracellular medium during tissue formation, it was wise to develop an artificial structure that mimics the extracellular matrix while having improved physico-chemical properties. That is why the choice was focused on gelatin methacryloyl (GelMA), an inexpensive biocompatible hydrogel. Physicochemical and mechanical properties were improved by the incorporation of nanoparticles developed from two innovative fabrication processes: High shear fluid and low frequencies/high frequencies ultrasounds. Both rapeseed nanoliposomes and nanodroplets were successfully incorporated in the GelMA networks during the photo polymerization process. The impact on polymer microstructure was investigated by Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and enzymatic degradation investigations. Mechanical stability and viscoelastic tests were conducted to demonstrate the beneficial effect of the functionalization on GelMA hydrogels. Adding nanoparticles to GelMA improved the surface properties (porosity), tuned swelling, and degradability properties. In addition, we observed that nanoemulsion didn’t change significantly the mechanical properties to shear and compression solicitations, whereas nanoliposome addition decreased Young’s modulus under compression solicitations. Thus, these ways of functionalization allow controlling the design of the material by choosing the type of nanoparticle (nanoliposome or nanoemulsion) in function of the application. MDPI 2017-12-10 /pmc/articles/PMC5751277/ /pubmed/29232870 http://dx.doi.org/10.3390/ijms18122675 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rahali, Kamel Ben Messaoud, Ghazi Kahn, Cyril J.F. Sanchez-Gonzalez, Laura Kaci, Mouna Cleymand, Franck Fleutot, Solenne Linder, Michel Desobry, Stéphane Arab-Tehrany, Elmira Synthesis and Characterization of Nanofunctionalized Gelatin Methacrylate Hydrogels |
title | Synthesis and Characterization of Nanofunctionalized Gelatin Methacrylate Hydrogels |
title_full | Synthesis and Characterization of Nanofunctionalized Gelatin Methacrylate Hydrogels |
title_fullStr | Synthesis and Characterization of Nanofunctionalized Gelatin Methacrylate Hydrogels |
title_full_unstemmed | Synthesis and Characterization of Nanofunctionalized Gelatin Methacrylate Hydrogels |
title_short | Synthesis and Characterization of Nanofunctionalized Gelatin Methacrylate Hydrogels |
title_sort | synthesis and characterization of nanofunctionalized gelatin methacrylate hydrogels |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751277/ https://www.ncbi.nlm.nih.gov/pubmed/29232870 http://dx.doi.org/10.3390/ijms18122675 |
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