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Predicting the Functional Impact of CDH1 Missense Mutations in Hereditary Diffuse Gastric Cancer
The role of E-cadherin in Hereditary Diffuse Gastric Cancer (HDGC) is unequivocal. Germline alterations in its encoding gene (CDH1) are causative of HDGC and occur in about 40% of patients. Importantly, while in most cases CDH1 alterations result in the complete loss of E-cadherin associated with a...
Autores principales: | Melo, Soraia, Figueiredo, Joana, Fernandes, Maria Sofia, Gonçalves, Margarida, Morais-de-Sá, Eurico, Sanches, João Miguel, Seruca, Raquel |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751289/ https://www.ncbi.nlm.nih.gov/pubmed/29231860 http://dx.doi.org/10.3390/ijms18122687 |
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