Cargando…

Major Challenges and Potential Microenvironment-Targeted Therapies in Glioblastoma

Glioblastoma (GBM) is considered one of the most malignant, genetically heterogeneous, and therapy-resistant solid tumor. Therapeutic options are limited in GBM and involve surgical resection followed by chemotherapy and/or radiotherapy. Adjuvant therapies, including antiangiogenic treatments (AATs)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Arbab, Ali S., Rashid, Mohammad H., Angara, Kartik, Borin, Thaiz F., Lin, Ping-Chang, Jain, Meenu, Achyut, Bhagelu R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751333/ https://www.ncbi.nlm.nih.gov/pubmed/29258180 http://dx.doi.org/10.3390/ijms18122732

Ejemplares similares

Changes in the tumor microenvironment and outcome for TME-targeting therapy in glioblastoma: A pilot study
por: Ali, Sehar, et al.
Publicado: (2021)

Arachidonic Acid Metabolite as a Novel Therapeutic Target in Breast Cancer Metastasis
por: Borin, Thaiz F., et al.
Publicado: (2017)

CXCR2-Expressing Tumor Cells Drive Vascular Mimicry in Antiangiogenic Therapy–Resistant Glioblastoma
por: Angara, Kartik, et al.
Publicado: (2018)

HET0016 decreases lung metastasis from breast cancer in immune-competent mouse model
por: Borin, Thaiz F., et al.
Publicado: (2017)

Vascular Mimicry: A Novel Neovascularization Mechanism Driving Anti-Angiogenic Therapy (AAT) Resistance in Glioblastoma
por: Angara, Kartik, et al.
Publicado: (2017)

Critical immunosuppressive effect of MDSC-derived exosomes in the tumor microenvironment
por: Rashid, Mohammad H., et al.
Publicado: (2021)

Canonical NFκB signaling in myeloid cells is required for the glioblastoma growth
por: Achyut, B. R., et al.
Publicado: (2017)

Intravenous Formulation of HET0016 Decreased Human Glioblastoma Growth and Implicated Survival Benefit in Rat Xenograft Models
por: Jain, Meenu, et al.
Publicado: (2017)

Cancer Therapeutics Following Newton’s Third Law
por: Arbab, Ali S., et al.
Publicado: (2016)

Vascular Mimicry: The Next Big Glioblastoma Target
por: Arbab, Ali S, et al.
Publicado: (2015)

Myeloid cell signatures in tumor microenvironment predicts therapeutic response in cancer
por: Achyut, Bhagelu R, et al.
Publicado: (2016)

Combination of vatalanib and a 20-HETE synthesis inhibitor results in decreased tumor growth in an animal model of human glioma
por: Shankar, Adarsh, et al.
Publicado: (2016)

When Seed and Soil Theory Meets Chicken or Egg Theory in Cancer Metastasis
por: Jain, Meenu, et al.
Publicado: (2015)

Delineating Pro-Angiogenic Myeloid Cells in Cancer Therapy
por: Johnson, Benjamin W., et al.
Publicado: (2018)

Malignant pericytes expressing GT198 give rise to tumor cells through angiogenesis
por: Zhang, Liyong, et al.
Publicado: (2017)

Differential biodistribution of intravenously administered endothelial progenitor and cytotoxic T-cells in rat bearing orthotopic human glioma
por: Varma, Nadimpalli Ravi S, et al.
Publicado: (2013)

Mechanisms of immune modulation in the tumor microenvironment and implications for targeted therapy
por: Czajka-Francuz, Paulina, et al.
Publicado: (2023)

Challenges in Immunotherapy Presented by the Glioblastoma Multiforme Microenvironment
por: Jackson, Christopher, et al.
Publicado: (2011)

Myeloid Derived Suppressor Cells: Fuel the Fire
por: Achyut, B. R., et al.
Publicado: (2014)

Targeting the TREM1-positive myeloid microenvironment in glioblastoma
por: Filippova, Natalia, et al.
Publicado: (2022)

Glioblastoma Microenvironment and Invasiveness: New Insights and Therapeutic Targets
por: Erices, José Ignacio, et al.
Publicado: (2023)

Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways
por: Chowdhury, Fabliha Ahmed, et al.
Publicado: (2018)

Effect of Melatonin on Tumor Growth and Angiogenesis in Xenograft Model of Breast Cancer
por: Jardim-Perassi, Bruna Victorasso, et al.
Publicado: (2014)

CD73 on cancer-associated fibroblasts enhanced by the A(2B)-mediated feedforward circuit enforces an immune checkpoint
por: Yu, Miao, et al.
Publicado: (2020)

The Interplay between Glioblastoma and Its Microenvironment
por: Dapash, Mark, et al.
Publicado: (2021)

Melatonin Modulates the Microenvironment of Glioblastoma Multiforme by Targeting Sirtuin 1
por: Lai, Sheng-Wei, et al.
Publicado: (2019)

Immune Modulatory Short Noncoding RNAs Targeting the Glioblastoma Microenvironment
por: Wei, Jun, et al.
Publicado: (2021)

Erratum to: Targeting the TREM1-positive myeloid microenvironment in glioblastoma
Publicado: (2023)

Glioblastoma microenvironment and its reprogramming by oncolytic virotherapy
por: Qi, Zhongbing, et al.
Publicado: (2022)

HET0016, a Selective Inhibitor of 20-HETE Synthesis, Decreases Pro-Angiogenic Factors and Inhibits Growth of Triple Negative Breast Cancer in Mice
por: Borin, Thaiz Ferraz, et al.
Publicado: (2014)

RNA modification patterns based on major RNA modifications define tumor microenvironment characteristics in glioblastoma
por: Li, Ganglei, et al.
Publicado: (2022)

Immune Microenvironment in Glioblastoma Subtypes
por: Chen, Zhihong, et al.
Publicado: (2018)

Glioblastoma: Microenvironment and Niche Concept
por: Schiffer, Davide, et al.
Publicado: (2018)

Modes of immunosuppression in glioblastoma microenvironment
por: Lehtipuro, Suvi, et al.
Publicado: (2019)

Myeloid Cells in Glioblastoma Microenvironment
por: De Leo, Alessandra, et al.
Publicado: (2020)

Multiple Faces of the Glioblastoma Microenvironment
por: Șovrea, Alina Simona, et al.
Publicado: (2022)

Glioblastoma Microenvironment and Cellular Interactions
por: Crivii, Carmen-Bianca, et al.
Publicado: (2022)

Macrophages in the Glioblastoma Tumor Microenvironment
por: Coniglio, Salvatore J.
Publicado: (2023)

CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment
por: Seyfrid, Mathieu, et al.
Publicado: (2022)

Behaviors of Glioblastoma Cells in in Vitro Microenvironments
por: Diao, Wenwen, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_acicthqnc0i2f5vgn24ugdohej