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Nrf2, the Master Regulator of Anti-Oxidative Responses

Tight regulation of inflammation is very important to guarantee a balanced immune response without developing chronic inflammation. One of the major mediators of the resolution of inflammation is the transcription factor: the nuclear factor erythroid 2-like 2 (Nrf2). Stabilized following oxidative s...

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Autores principales: Vomund, Sandra, Schäfer, Anne, Parnham, Michael J., Brüne, Bernhard, von Knethen, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751370/
https://www.ncbi.nlm.nih.gov/pubmed/29261130
http://dx.doi.org/10.3390/ijms18122772
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author Vomund, Sandra
Schäfer, Anne
Parnham, Michael J.
Brüne, Bernhard
von Knethen, Andreas
author_facet Vomund, Sandra
Schäfer, Anne
Parnham, Michael J.
Brüne, Bernhard
von Knethen, Andreas
author_sort Vomund, Sandra
collection PubMed
description Tight regulation of inflammation is very important to guarantee a balanced immune response without developing chronic inflammation. One of the major mediators of the resolution of inflammation is the transcription factor: the nuclear factor erythroid 2-like 2 (Nrf2). Stabilized following oxidative stress, Nrf2 induces the expression of antioxidants as well as cytoprotective genes, which provoke an anti-inflammatory expression profile, and is crucial for the initiation of healing. In view of this fundamental modulatory role, it is clear that both hyper- or hypoactivation of Nrf2 contribute to the onset of chronic diseases. Understanding the tight regulation of Nrf2 expression/activation and its interaction with signaling pathways, known to affect inflammatory processes, will facilitate development of therapeutic approaches to prevent Nrf2 dysregulation and ameliorate chronic inflammatory diseases. We discuss in this review the principle mechanisms of Nrf2 regulation with a focus on inflammation and autophagy, extending the role of dysregulated Nrf2 to chronic diseases and tumor development.
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spelling pubmed-57513702018-01-08 Nrf2, the Master Regulator of Anti-Oxidative Responses Vomund, Sandra Schäfer, Anne Parnham, Michael J. Brüne, Bernhard von Knethen, Andreas Int J Mol Sci Review Tight regulation of inflammation is very important to guarantee a balanced immune response without developing chronic inflammation. One of the major mediators of the resolution of inflammation is the transcription factor: the nuclear factor erythroid 2-like 2 (Nrf2). Stabilized following oxidative stress, Nrf2 induces the expression of antioxidants as well as cytoprotective genes, which provoke an anti-inflammatory expression profile, and is crucial for the initiation of healing. In view of this fundamental modulatory role, it is clear that both hyper- or hypoactivation of Nrf2 contribute to the onset of chronic diseases. Understanding the tight regulation of Nrf2 expression/activation and its interaction with signaling pathways, known to affect inflammatory processes, will facilitate development of therapeutic approaches to prevent Nrf2 dysregulation and ameliorate chronic inflammatory diseases. We discuss in this review the principle mechanisms of Nrf2 regulation with a focus on inflammation and autophagy, extending the role of dysregulated Nrf2 to chronic diseases and tumor development. MDPI 2017-12-20 /pmc/articles/PMC5751370/ /pubmed/29261130 http://dx.doi.org/10.3390/ijms18122772 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vomund, Sandra
Schäfer, Anne
Parnham, Michael J.
Brüne, Bernhard
von Knethen, Andreas
Nrf2, the Master Regulator of Anti-Oxidative Responses
title Nrf2, the Master Regulator of Anti-Oxidative Responses
title_full Nrf2, the Master Regulator of Anti-Oxidative Responses
title_fullStr Nrf2, the Master Regulator of Anti-Oxidative Responses
title_full_unstemmed Nrf2, the Master Regulator of Anti-Oxidative Responses
title_short Nrf2, the Master Regulator of Anti-Oxidative Responses
title_sort nrf2, the master regulator of anti-oxidative responses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751370/
https://www.ncbi.nlm.nih.gov/pubmed/29261130
http://dx.doi.org/10.3390/ijms18122772
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