Exploration of charge states of balanol analogues acting as ATP-competitive inhibitors in kinases

BACKGROUND: (-)-Balanol is an ATP mimic that inhibits protein kinase C (PKC) isozymes and cAMP-dependent protein kinase (PKA) with limited selectivity. While PKA is a tumour promoter, PKC isozymes act as tumour promoters or suppressors, depending on the cancer type. In particular, PKCε is frequently...

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Detalles Bibliográficos
Autores principales: Hardianto, Ari, Yusuf, Muhammad, Liu, Fei, Ranganathan, Shoba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751415/
https://www.ncbi.nlm.nih.gov/pubmed/29297286
http://dx.doi.org/10.1186/s12859-017-1955-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751415/
https://www.ncbi.nlm.nih.gov/pubmed/29297286
http://dx.doi.org/10.1186/s12859-017-1955-7

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