High resolution melting curve analysis targeting the HBB gene mutational hot-spot offers a reliable screening approach for all common as well as most of the rare beta-globin gene mutations in Bangladesh

BACKGROUND: Bangladesh lies in the global thalassemia belt, which has a defined mutational hot-spot in the beta-globin gene. The high carrier frequencies of beta-thalassemia trait and hemoglobin E-trait in Bangladesh necessitate a reliable DNA-based carrier screening approach that could supplement t...

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Detalles Bibliográficos
Autores principales: Islam, Md Tarikul, Sarkar, Suprovath Kumar, Sultana, Nusrat, Begum, Mst. Noorjahan, Bhuyan, Golam Sarower, Talukder, Shezote, Muraduzzaman, A. K. M., Alauddin, Md, Islam, Mohammad Sazzadul, Biswas, Pritha Promita, Biswas, Aparna, Qadri, Syeda Kashfi, Shirin, Tahmina, Banu, Bilquis, Sadya, Salma, Hussain, Manzoor, Sarwardi, Golam, Khan, Waqar Ahmed, Mannan, Mohammad Abdul, Shekhar, Hossain Uddin, Chowdhury, Emran Kabir, Sajib, Abu Ashfaqur, Akhteruzzaman, Sharif, Qadri, Syed Saleheen, Qadri, Firdausi, Mannoor, Kaiissar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751541/
https://www.ncbi.nlm.nih.gov/pubmed/29295702
http://dx.doi.org/10.1186/s12863-017-0594-3

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