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Phase-Sensitive Surface Plasmon Resonance Sensors: Recent Progress and Future Prospects
Surface plasmon resonance (SPR) is an optical sensing technique that is capable of performing real-time, label-free and high-sensitivity monitoring of molecular interactions. SPR biosensors can be divided according to their operating principles into angle-, wavelength-, intensity- and phase-interrog...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751602/ https://www.ncbi.nlm.nih.gov/pubmed/29206182 http://dx.doi.org/10.3390/s17122819 |
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author | Deng, Shijie Wang, Peng Yu, Xinglong |
author_facet | Deng, Shijie Wang, Peng Yu, Xinglong |
author_sort | Deng, Shijie |
collection | PubMed |
description | Surface plasmon resonance (SPR) is an optical sensing technique that is capable of performing real-time, label-free and high-sensitivity monitoring of molecular interactions. SPR biosensors can be divided according to their operating principles into angle-, wavelength-, intensity- and phase-interrogated devices. With their complex optical configurations, phase-interrogated SPR sensors generally provide higher sensitivity and throughput, and have thus recently emerged as prominent biosensing devices. To date, several methods have been developed for SPR phase interrogation, including heterodyne detection, polarimetry, shear interferometry, spatial phase modulation interferometry and temporal phase modulation interferometry. This paper summarizes the fundamentals of phase-sensitive SPR sensing, reviews the available methods for phase interrogation of these sensors, and discusses the future prospects for and trends in the development of this technology. |
format | Online Article Text |
id | pubmed-5751602 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57516022018-01-10 Phase-Sensitive Surface Plasmon Resonance Sensors: Recent Progress and Future Prospects Deng, Shijie Wang, Peng Yu, Xinglong Sensors (Basel) Review Surface plasmon resonance (SPR) is an optical sensing technique that is capable of performing real-time, label-free and high-sensitivity monitoring of molecular interactions. SPR biosensors can be divided according to their operating principles into angle-, wavelength-, intensity- and phase-interrogated devices. With their complex optical configurations, phase-interrogated SPR sensors generally provide higher sensitivity and throughput, and have thus recently emerged as prominent biosensing devices. To date, several methods have been developed for SPR phase interrogation, including heterodyne detection, polarimetry, shear interferometry, spatial phase modulation interferometry and temporal phase modulation interferometry. This paper summarizes the fundamentals of phase-sensitive SPR sensing, reviews the available methods for phase interrogation of these sensors, and discusses the future prospects for and trends in the development of this technology. MDPI 2017-12-05 /pmc/articles/PMC5751602/ /pubmed/29206182 http://dx.doi.org/10.3390/s17122819 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Deng, Shijie Wang, Peng Yu, Xinglong Phase-Sensitive Surface Plasmon Resonance Sensors: Recent Progress and Future Prospects |
title | Phase-Sensitive Surface Plasmon Resonance Sensors: Recent Progress and Future Prospects |
title_full | Phase-Sensitive Surface Plasmon Resonance Sensors: Recent Progress and Future Prospects |
title_fullStr | Phase-Sensitive Surface Plasmon Resonance Sensors: Recent Progress and Future Prospects |
title_full_unstemmed | Phase-Sensitive Surface Plasmon Resonance Sensors: Recent Progress and Future Prospects |
title_short | Phase-Sensitive Surface Plasmon Resonance Sensors: Recent Progress and Future Prospects |
title_sort | phase-sensitive surface plasmon resonance sensors: recent progress and future prospects |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751602/ https://www.ncbi.nlm.nih.gov/pubmed/29206182 http://dx.doi.org/10.3390/s17122819 |
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