Development of models for predicting Torsade de Pointes cardiac arrhythmias using perceptron neural networks

BACKGROUND: Blockage of some ion channels and in particular, the hERG (human Ether-a’-go-go-Related Gene) cardiac potassium channel delays cardiac repolarization and can induce arrhythmia. In some cases it leads to a potentially life-threatening arrhythmia known as Torsade de Pointes (TdP). Therefor...

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Detalles Bibliográficos
Autores principales: Sharifi, Mohsen, Buzatu, Dan, Harris, Stephen, Wilkes, Jon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751783/
https://www.ncbi.nlm.nih.gov/pubmed/29297274
http://dx.doi.org/10.1186/s12859-017-1895-2

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