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TP53 R72P Polymorphism and Susceptibility to Human Papillomavirus Infection Among Women With Human Immunodeficiency Virus in Morocco: A Case-control Study

BACKGROUND: Human papillomavirus (HPV) is the most common sexually transmitted agent worldwide. HPV is the main causative agent for cervical cancer. The HPV oncoprotein E6 binds to the tumor suppressor gene product p53, promoting its degradation; the Arg allele of TP53 R72P polymorphism binds more a...

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Autores principales: Lahsen, Ahd Oulad, Baba, Hanâ, Bensghir, Rajaa, Fayssel, Naouar, Sodqi, Mustapha, Marih, Latifa, Nadifi, Sellama, Wakrim, Lahcen, El Filali, Kamal Marhoum, Ezzikouri, Sayeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Cancer Prevention 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751843/
https://www.ncbi.nlm.nih.gov/pubmed/29302583
http://dx.doi.org/10.15430/JCP.2017.22.4.248
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author Lahsen, Ahd Oulad
Baba, Hanâ
Bensghir, Rajaa
Fayssel, Naouar
Sodqi, Mustapha
Marih, Latifa
Nadifi, Sellama
Wakrim, Lahcen
El Filali, Kamal Marhoum
Ezzikouri, Sayeh
author_facet Lahsen, Ahd Oulad
Baba, Hanâ
Bensghir, Rajaa
Fayssel, Naouar
Sodqi, Mustapha
Marih, Latifa
Nadifi, Sellama
Wakrim, Lahcen
El Filali, Kamal Marhoum
Ezzikouri, Sayeh
author_sort Lahsen, Ahd Oulad
collection PubMed
description BACKGROUND: Human papillomavirus (HPV) is the most common sexually transmitted agent worldwide. HPV is the main causative agent for cervical cancer. The HPV oncoprotein E6 binds to the tumor suppressor gene product p53, promoting its degradation; the Arg allele of TP53 R72P polymorphism binds more ardently with HPV E6 than the Pro variant. Here, we investigated whether TP53 R72P gene variant, rs104252, was associated with susceptibility to HPV infection in women with human immunodeficiency virus (HIV). METHODS: We analyzed 200 HPV-positive and 68 uninfected women with HIV. Genomic DNA was isolated from cervical swab. The TP53 R72P polymorphism was genotyped by PCR-RFLP. Unconditional logistic regression was used to assess the association between polymorphism and the clinical, lifestyle, and behavioral data. RESULTS: The genotype and allele frequencies of rs104252 variant did not differ between women without or with HPV infection (P > 0.05). Moreover, the p53 polymorphism was not associated with cervical cytology. In contrast, when we analyzed according to behavior factors, the P72P genotype was more frequent among HPV-positive smoker women. However, no significant relationship was found between alcohol, contraceptive use, and number of partners with TP53 R72P genotype distributions among HPV-positive cases (P > 0.05). CONCLUSIONS: The R72 variant of p53 R72P is not associated with HPV infection and progression of lesions. There was no association between this variant and behavior factors in HPV-positive cases. The P72P genotype may be more frequent among HPV-positive smoker women.
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spelling pubmed-57518432018-01-04 TP53 R72P Polymorphism and Susceptibility to Human Papillomavirus Infection Among Women With Human Immunodeficiency Virus in Morocco: A Case-control Study Lahsen, Ahd Oulad Baba, Hanâ Bensghir, Rajaa Fayssel, Naouar Sodqi, Mustapha Marih, Latifa Nadifi, Sellama Wakrim, Lahcen El Filali, Kamal Marhoum Ezzikouri, Sayeh J Cancer Prev Original Article BACKGROUND: Human papillomavirus (HPV) is the most common sexually transmitted agent worldwide. HPV is the main causative agent for cervical cancer. The HPV oncoprotein E6 binds to the tumor suppressor gene product p53, promoting its degradation; the Arg allele of TP53 R72P polymorphism binds more ardently with HPV E6 than the Pro variant. Here, we investigated whether TP53 R72P gene variant, rs104252, was associated with susceptibility to HPV infection in women with human immunodeficiency virus (HIV). METHODS: We analyzed 200 HPV-positive and 68 uninfected women with HIV. Genomic DNA was isolated from cervical swab. The TP53 R72P polymorphism was genotyped by PCR-RFLP. Unconditional logistic regression was used to assess the association between polymorphism and the clinical, lifestyle, and behavioral data. RESULTS: The genotype and allele frequencies of rs104252 variant did not differ between women without or with HPV infection (P > 0.05). Moreover, the p53 polymorphism was not associated with cervical cytology. In contrast, when we analyzed according to behavior factors, the P72P genotype was more frequent among HPV-positive smoker women. However, no significant relationship was found between alcohol, contraceptive use, and number of partners with TP53 R72P genotype distributions among HPV-positive cases (P > 0.05). CONCLUSIONS: The R72 variant of p53 R72P is not associated with HPV infection and progression of lesions. There was no association between this variant and behavior factors in HPV-positive cases. The P72P genotype may be more frequent among HPV-positive smoker women. Korean Society of Cancer Prevention 2017-12 2017-12-30 /pmc/articles/PMC5751843/ /pubmed/29302583 http://dx.doi.org/10.15430/JCP.2017.22.4.248 Text en Copyright © 2017 Korean Society of Cancer Prevention This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lahsen, Ahd Oulad
Baba, Hanâ
Bensghir, Rajaa
Fayssel, Naouar
Sodqi, Mustapha
Marih, Latifa
Nadifi, Sellama
Wakrim, Lahcen
El Filali, Kamal Marhoum
Ezzikouri, Sayeh
TP53 R72P Polymorphism and Susceptibility to Human Papillomavirus Infection Among Women With Human Immunodeficiency Virus in Morocco: A Case-control Study
title TP53 R72P Polymorphism and Susceptibility to Human Papillomavirus Infection Among Women With Human Immunodeficiency Virus in Morocco: A Case-control Study
title_full TP53 R72P Polymorphism and Susceptibility to Human Papillomavirus Infection Among Women With Human Immunodeficiency Virus in Morocco: A Case-control Study
title_fullStr TP53 R72P Polymorphism and Susceptibility to Human Papillomavirus Infection Among Women With Human Immunodeficiency Virus in Morocco: A Case-control Study
title_full_unstemmed TP53 R72P Polymorphism and Susceptibility to Human Papillomavirus Infection Among Women With Human Immunodeficiency Virus in Morocco: A Case-control Study
title_short TP53 R72P Polymorphism and Susceptibility to Human Papillomavirus Infection Among Women With Human Immunodeficiency Virus in Morocco: A Case-control Study
title_sort tp53 r72p polymorphism and susceptibility to human papillomavirus infection among women with human immunodeficiency virus in morocco: a case-control study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751843/
https://www.ncbi.nlm.nih.gov/pubmed/29302583
http://dx.doi.org/10.15430/JCP.2017.22.4.248
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