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Inflammation-Generated Extracellular Matrix Fragments Drive Lung Metastasis

Mechanisms explaining the propensity of a primary tumor to metastasize to a specific site still need to be unveiled, and clinical studies support a link between chronic inflammation and cancer dissemination to specific tissues. Using different mouse models, we demonstrate the role of inflammation-ge...

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Autores principales: Bekaert, Sandrine, Fillet, Marianne, Detry, Benoit, Pichavant, Muriel, Marée, Raphael, Noel, Agnes, Rocks, Natacha, Cataldo, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751907/
https://www.ncbi.nlm.nih.gov/pubmed/29308014
http://dx.doi.org/10.1177/1179064417745539
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author Bekaert, Sandrine
Fillet, Marianne
Detry, Benoit
Pichavant, Muriel
Marée, Raphael
Noel, Agnes
Rocks, Natacha
Cataldo, Didier
author_facet Bekaert, Sandrine
Fillet, Marianne
Detry, Benoit
Pichavant, Muriel
Marée, Raphael
Noel, Agnes
Rocks, Natacha
Cataldo, Didier
author_sort Bekaert, Sandrine
collection PubMed
description Mechanisms explaining the propensity of a primary tumor to metastasize to a specific site still need to be unveiled, and clinical studies support a link between chronic inflammation and cancer dissemination to specific tissues. Using different mouse models, we demonstrate the role of inflammation-generated extracellular matrix fragments ac-PGP (N-acetyl-proline-glycine-proline) on tumor cells dissemination to lung parenchyma. In mice exposed to cigarette smoke or lipopolysaccharide, lung neutrophilic inflammation produces increased levels of MMP-9 (matrix metalloproteinase 9) that contributes to collagen breakdown and allows the release of ac-PGP tripeptides. By silencing CXCR2 gene expression in tumor cells, we show that these generated ac-PGP tripeptides exert a chemotactic activity on tumor cells in vivo by binding CXCR2.
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spelling pubmed-57519072018-01-05 Inflammation-Generated Extracellular Matrix Fragments Drive Lung Metastasis Bekaert, Sandrine Fillet, Marianne Detry, Benoit Pichavant, Muriel Marée, Raphael Noel, Agnes Rocks, Natacha Cataldo, Didier Cancer Growth Metastasis Original Research Mechanisms explaining the propensity of a primary tumor to metastasize to a specific site still need to be unveiled, and clinical studies support a link between chronic inflammation and cancer dissemination to specific tissues. Using different mouse models, we demonstrate the role of inflammation-generated extracellular matrix fragments ac-PGP (N-acetyl-proline-glycine-proline) on tumor cells dissemination to lung parenchyma. In mice exposed to cigarette smoke or lipopolysaccharide, lung neutrophilic inflammation produces increased levels of MMP-9 (matrix metalloproteinase 9) that contributes to collagen breakdown and allows the release of ac-PGP tripeptides. By silencing CXCR2 gene expression in tumor cells, we show that these generated ac-PGP tripeptides exert a chemotactic activity on tumor cells in vivo by binding CXCR2. SAGE Publications 2017-12-21 /pmc/articles/PMC5751907/ /pubmed/29308014 http://dx.doi.org/10.1177/1179064417745539 Text en © The Author(s) 2017 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Bekaert, Sandrine
Fillet, Marianne
Detry, Benoit
Pichavant, Muriel
Marée, Raphael
Noel, Agnes
Rocks, Natacha
Cataldo, Didier
Inflammation-Generated Extracellular Matrix Fragments Drive Lung Metastasis
title Inflammation-Generated Extracellular Matrix Fragments Drive Lung Metastasis
title_full Inflammation-Generated Extracellular Matrix Fragments Drive Lung Metastasis
title_fullStr Inflammation-Generated Extracellular Matrix Fragments Drive Lung Metastasis
title_full_unstemmed Inflammation-Generated Extracellular Matrix Fragments Drive Lung Metastasis
title_short Inflammation-Generated Extracellular Matrix Fragments Drive Lung Metastasis
title_sort inflammation-generated extracellular matrix fragments drive lung metastasis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751907/
https://www.ncbi.nlm.nih.gov/pubmed/29308014
http://dx.doi.org/10.1177/1179064417745539
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