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Loss of PACS-2 delays regeneration in DSS-induced colitis but does not affect the Apc(Min) model of colorectal cancer

PACS-2 is a multifunctional sorting protein that mediates cell homeostasis. We recently identified PACS-2 in a functional genome-wide siRNA screen for novel regulators of the metalloproteinase ADAM17, the main sheddase for ligands of the ErbB receptor family. Of note, we showed that Pacs2(-/-) mice...

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Detalles Bibliográficos
Autores principales:	Dombernowsky, Sarah L., Schwarz, Jeanette, Samsøe-Petersen, Jacob, Albrechtsen, Reidar, Jensen, Kim B., Thomas, Gary, Kveiborg, Marie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752446/ https://www.ncbi.nlm.nih.gov/pubmed/29312533 http://dx.doi.org/10.18632/oncotarget.22661

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