Deletion lengthening at chromosomes 6q and 16q targets multiple tumor suppressor genes and is associated with an increasingly poor prognosis in prostate cancer

Prostate cancer is characterized by recurrent deletions that can considerably vary in size. We hypothesized that large deletions develop from small deletions and that this “deletion lengthening” might have a “per se” carcinogenic role through a combinatorial effect of multiple down regulated genes....

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Detalles Bibliográficos
Autores principales: Kluth, Martina, Jung, Simon, Habib, Omar, Eshagzaiy, Mina, Heinl, Anna, Amschler, Nina, Masser, Sawinee, Mader, Malte, Runte, Frederic, Barow, Philipp, Frogh, Sohall, Omari, Jazan, Möller-Koop, Christina, Hube-Magg, Claudia, Weischenfeldt, Joachim, Korbel, Jan, Steurer, Stefan, Krech, Till, Huland, Hartwig, Graefen, Markus, Minner, Sarah, Sauter, Guido, Schlomm, Thorsten, Simon, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752492/
https://www.ncbi.nlm.nih.gov/pubmed/29312579
http://dx.doi.org/10.18632/oncotarget.22408

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