Glucose impairs tamoxifen responsiveness modulating connective tissue growth factor in breast cancer cells

Type 2 diabetes and obesity are negative prognostic factors in patients with breast cancer (BC). We found that sensitivity to tamoxifen was reduced by 2-fold by 25 mM glucose (High Glucose; HG) compared to 5.5 mM glucose (Low Glucose; LG) in MCF7 BC cells. Shifting from HG to LG ameliorated MCF7 cel...

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Detalles Bibliográficos
Autores principales: Ambrosio, Maria Rosaria, D’Esposito, Vittoria, Costa, Valerio, Liguoro, Domenico, Collina, Francesca, Cantile, Monica, Prevete, Nella, Passaro, Carmela, Mosca, Giusy, De Laurentiis, Michelino, Di Bonito, Maurizio, Botti, Gerardo, Franco, Renato, Beguinot, Francesco, Ciccodicola, Alfredo, Formisano, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752499/
https://www.ncbi.nlm.nih.gov/pubmed/29312586
http://dx.doi.org/10.18632/oncotarget.22552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752499/
https://www.ncbi.nlm.nih.gov/pubmed/29312586
http://dx.doi.org/10.18632/oncotarget.22552

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