Cargando…

Shikonin induces ROS-based mitochondria-mediated apoptosis in colon cancer

Colon cancer is the third most common malignancy worldwide, and chemotherapy is a widely used strategy in clinical therapy. Chemotherapy-resistant of colon cancer is the main cause of recurrence and progression. Novel drugs with efficacy and safety in treating colon cancer are urgently needed. Shiko...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liang, Wenquan, Cui, Jianxin, Zhang, Kecheng, Xi, Hongqing, Cai, Aizhen, Li, Jiyang, Gao, Yunhe, Hu, Chong, Liu, Yi, Lu, Yixun, Wang, Ning, Wu, Xiaosong, Wei, Bo, Chen, Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752506/ https://www.ncbi.nlm.nih.gov/pubmed/29312593 http://dx.doi.org/10.18632/oncotarget.22618

Ejemplares similares

Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species
por: Liang, Wenquan, et al.
Publicado: (2016)

Evaluation of hepatectomy and palliative local treatments for gastric cancer patients with liver metastases: a propensity score matching analysis
por: Li, Jiyang, et al.
Publicado: (2017)

Diagnostic and prognostic value of circulating tumor DNA in gastric cancer: a meta-analysis
por: Gao, Yunhe, et al.
Publicado: (2016)

Ring finger protein 43 associates with gastric cancer progression and attenuates the stemness of gastric cancer stem-like cells via the Wnt-β/catenin signaling pathway
por: Gao, Yunhe, et al.
Publicado: (2017)

Association of thymidylate synthase expression and clinical outcomes of gastric cancer patients treated with fluoropyrimidine-based chemotherapy: a meta-analysis
por: Gao, Yunhe, et al.
Publicado: (2016)

Genome-Wide lncRNA Microarray Profiling Identifies Novel Circulating lncRNAs for Detection of Gastric Cancer
por: Zhang, Kecheng, et al.
Publicado: (2017)

Defining the impact of platelet-to-lymphocyte ratio on patient survival with gastric neuroendocrine neoplasm: a retrospective cohort analysis
por: Liang, Wenquan, et al.
Publicado: (2022)

Prolonged postoperative ileus in gastric surgery: Is there any difference between laparoscopic and open surgery?
por: Liang, Wenquan, et al.
Publicado: (2019)

Tumor deposit serves as a prognostic marker in gastric cancer: A propensity score‐matched analysis comparing survival outcomes
por: Wenquan, Liang, et al.
Publicado: (2020)

Shikonin Induces ROS-Dependent Apoptosis Via Mitochondria Depolarization and ER Stress in Adult T Cell Leukemia/Lymphoma
por: Boonnate, Piyanard, et al.
Publicado: (2023)

Ability of Serum C-Reactive Protein Concentrations to Predict Complications After Laparoscopy-Assisted Gastrectomy: A Prospective Cohort Study
por: Zhang, Kecheng, et al.
Publicado: (2016)

Association Between Liquid Biopsy and Prognosis of Gastric Cancer Patients: A Systematic Review and Meta-Analysis
por: Gao, Yunhe, et al.
Publicado: (2019)

Robot-Assisted Versus Laparoscopy-Assisted Proximal Gastrectomy for Early Gastric Cancer in the Upper Location: Comparison of Oncological Outcomes, Surgical Stress, and Nutritional Status
por: Zhang, Kecheng, et al.
Publicado: (2018)

Stearoyl-CoA-desaturase-1 regulates gastric cancer stem-like properties and promotes tumour metastasis via Hippo/YAP pathway
por: Gao, Yunhe, et al.
Publicado: (2020)

Shikonin induces apoptosis in the human gastric cancer cells HGC-27 through mitochondria-mediated pathway
por: Hou, Yue, et al.
Publicado: (2015)

Lymph Node Yield Following Packet Submission After Isolation By Surgeon During Gastrectomy
por: Wang, Pengpeng, et al.
Publicado: (2019)

JS‐K induces reactive oxygen species‐dependent anti‐cancer effects by targeting mitochondria respiratory chain complexes in gastric cancer
por: Zhao, Xudong, et al.
Publicado: (2019)

Serum HER2 Is a Potential Surrogate for Tissue HER2 Status in Gastric Cancer: A Systematic Review and Meta-Analysis
por: Zhang, Kecheng, et al.
Publicado: (2015)

Long noncoding RNA AOC4P regulates tumor cell proliferation and invasion by epithelial–mesenchymal transition in gastric cancer
por: Zhang, Kecheng, et al.
Publicado: (2019)

Induction of apoptosis by Shikonin through ROS-mediated intrinsic and extrinsic apoptotic pathways in primary effusion lymphoma
por: Alam, Md Masud, et al.
Publicado: (2021)

Shikonin Inhibits the Proliferation of Human Lens Epithelial Cells by Inducing Apoptosis through ROS and Caspase-Dependent Pathway
por: Huang, Wan-Rong, et al.
Publicado: (2014)

MiR-144-3p inhibits gastric cancer progression and stemness via directly targeting GLI2 involved in hedgehog pathway
por: Lu, Yixun, et al.
Publicado: (2021)

Senescence Inducer Shikonin ROS-Dependently Suppressed Lung Cancer Progression
por: Zheng, Hongming, et al.
Publicado: (2018)

Shikonin Directly Targets Mitochondria and Causes Mitochondrial Dysfunction in Cancer Cells
por: Wiench, Benjamin, et al.
Publicado: (2012)

Shikonin induces mitochondria-mediated apoptosis and attenuates epithelial-mesenchymal transition in cisplatin-resistant human ovarian cancer cells
por: Shilnikova, Kristina, et al.
Publicado: (2018)

Phase II Trial of Adjuvant Immunotherapy with Autologous Tumor-derived Gp96 Vaccination in Patients with Gastric Cancer
por: Zhang, Kecheng, et al.
Publicado: (2017)

A novel Osmium-based compound targets the mitochondria and triggers ROS-dependent apoptosis in colon carcinoma
por: Maillet, A, et al.
Publicado: (2013)

Effect of preoperative nutrition therapy type and duration on short-time outcomes in gastric cancer patient with gastric outlet obstruction
por: Li, Jiyang, et al.
Publicado: (2021)

ROS mediated apoptotic pathways in primary effusion lymphoma: Comment on induction of apoptosis by Shikonin through ROS-mediated intrinsic and extrinsic pathways in primary effusion lymphoma
por: Dwivedi, Pankaj
Publicado: (2021)

Comparison of short-term outcomes and quality of life in totally laparoscopic distal gastrectomy and totally robotic distal gastrectomy for clinical stage I–III gastric cancer: study protocol for a multi-institutional randomised clinical trial
por: Cui, Hao, et al.
Publicado: (2021)

Prognostic role of extracellular matrix metalloproteinase inducer/CD147 in gastrointestinal cancer: a meta-analysis of related studies
por: Huang, Xiaohui, et al.
Publicado: (2016)

Shikonin Exerts Cytotoxic Effects in Human Colon Cancers by Inducing Apoptotic Cell Death via the Endoplasmic Reticulum and Mitochondria-Mediated Pathways
por: Han, Xia, et al.
Publicado: (2019)

Natural Compound Shikonin Induces Apoptosis and Attenuates Epithelial to Mesenchymal Transition in Radiation-Resistant Human Colon Cancer Cells
por: Shilnikova, Kristina, et al.
Publicado: (2022)

Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis
por: Zhang, Nan, et al.
Publicado: (2020)

Shikonin promotes adriamycin-induced apoptosis by upregulating caspase-3 and caspase-8 in osteosarcoma
por: Yang, Qing, et al.
Publicado: (2017)

Shikonin Inhibits Cancer Through P21 Upregulation and Apoptosis Induction
por: Wang, Fangfang, et al.
Publicado: (2020)

Integration of Transcriptomics and Metabolomics Reveals the Antitumor Mechanism Underlying Shikonin in Colon Cancer
por: Chen, Yang, et al.
Publicado: (2020)

RCC2 Interacts with Small GTPase RalA and Regulates Cell Proliferation and Motility in Gastric Cancer
por: Wang, Pengpeng, et al.
Publicado: (2020)

Corrigendum: Shikonin Inhibits Cancer Through P21 Upregulation and Apoptosis Induction
por: Wang, Fangfang, et al.
Publicado: (2020)

Shikonin inhibits proliferation of melanoma cells by MAPK pathway-mediated induction of apoptosis
por: Lee, Jae Han, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_crage0gqei7kl0jbp31et4uop9