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Pyruvate kinase M2 phosphorylates H2AX and promotes genomic instability in human tumor cells

Pyruvate kinase (PK) catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP, a rate-limiting reaction in glycolysis. M2 isoform of PK (PKM2) is the predominant form of PK expressed in tumors. In addition to its well established cytosolic functions as a glycolytic enzyme, PKM2 di...

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Detalles Bibliográficos
Autores principales:	Xia, Li, Qin, Kang, Wang, Xin-Ran, Wang, Xiao-Ling, Zhou, Ai-Wu, Chen, Guo-Qiang, Lu, Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752508/ https://www.ncbi.nlm.nih.gov/pubmed/29312595 http://dx.doi.org/10.18632/oncotarget.22621

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