3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiation

DNA double-strand breaks (DSBs) induced by ionising radiation are considered the major cause of genotoxic mutations and cell death. While DSBs are dispersed throughout chromatin after X-rays or γ-irradiation, multiple types of DNA damage including DSBs, single-strand breaks and base damage can be ge...

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Detalles Bibliográficos
Autores principales: Hagiwara, Yoshihiko, Niimi, Atsuko, Isono, Mayu, Yamauchi, Motohiro, Yasuhara, Takaaki, Limsirichaikul, Siripan, Oike, Takahiro, Sato, Hiro, Held, Kathryn D., Nakano, Takashi, Shibata, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752527/
https://www.ncbi.nlm.nih.gov/pubmed/29312614
http://dx.doi.org/10.18632/oncotarget.22679

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