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Elevated red blood cell distribution width predicts poor prognosis in hilar cholangiocarcinoma

BACKGROUND: Although the red blood cell distribution width (RDW) has been reported as a reliable predictor of prognosis in several types of cancer, the prognostic value of RDW in hilar cholangiocarcinoma (HC) has not been studied. METHODS: A retrospective analysis of 292 consecutively recruited HC p...

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Autores principales: Li, Bei, You, Zhen, Xiong, Xian-Ze, Zhou, Yong, Wu, Si-Jia, Zhou, Rong-Xing, Lu, Jiong, Cheng, Nan-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752534/
https://www.ncbi.nlm.nih.gov/pubmed/29312621
http://dx.doi.org/10.18632/oncotarget.22694
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author Li, Bei
You, Zhen
Xiong, Xian-Ze
Zhou, Yong
Wu, Si-Jia
Zhou, Rong-Xing
Lu, Jiong
Cheng, Nan-Sheng
author_facet Li, Bei
You, Zhen
Xiong, Xian-Ze
Zhou, Yong
Wu, Si-Jia
Zhou, Rong-Xing
Lu, Jiong
Cheng, Nan-Sheng
author_sort Li, Bei
collection PubMed
description BACKGROUND: Although the red blood cell distribution width (RDW) has been reported as a reliable predictor of prognosis in several types of cancer, the prognostic value of RDW in hilar cholangiocarcinoma (HC) has not been studied. METHODS: A retrospective analysis of 292 consecutively recruited HC patients undergoing radical resection was conducted. The optimal cutoff value of RDW was determined by the receiver operating characteristic curve (ROC). Survival analysis by the Kaplan-Meier method, the difference between the clinico-pathologic variables and survival were evaluated by log-rank analysis. Multivariate analysis identified independent prognostic risk factors of overall survival (OS). RESULTS: ROC analysis suggested that the optimal cutoff value for the RDW was 14.95. Linear correlation analysis revealed that RDW is associated with white blood cell count (P = 0.007), neutrophil-to-lymphocyte ratio (P = 0.02), and hemoglobin (P < 0.001), albumin (P < 0.001). In a multivariate analysis, the RDW was an independent prognostic factor for OS (HR = 1.755, 95% CI 1.311-2.349, P < 0.001). CONCLUSIONS: Elevated RDW may be regarded as an indicator of systemic inflammatory response which might facilitate HC growth and metastasis. Current evidence suggests that RDW may have clinical significance in predicting OS after surgery in HC patients.
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spelling pubmed-57525342018-01-08 Elevated red blood cell distribution width predicts poor prognosis in hilar cholangiocarcinoma Li, Bei You, Zhen Xiong, Xian-Ze Zhou, Yong Wu, Si-Jia Zhou, Rong-Xing Lu, Jiong Cheng, Nan-Sheng Oncotarget Research Paper BACKGROUND: Although the red blood cell distribution width (RDW) has been reported as a reliable predictor of prognosis in several types of cancer, the prognostic value of RDW in hilar cholangiocarcinoma (HC) has not been studied. METHODS: A retrospective analysis of 292 consecutively recruited HC patients undergoing radical resection was conducted. The optimal cutoff value of RDW was determined by the receiver operating characteristic curve (ROC). Survival analysis by the Kaplan-Meier method, the difference between the clinico-pathologic variables and survival were evaluated by log-rank analysis. Multivariate analysis identified independent prognostic risk factors of overall survival (OS). RESULTS: ROC analysis suggested that the optimal cutoff value for the RDW was 14.95. Linear correlation analysis revealed that RDW is associated with white blood cell count (P = 0.007), neutrophil-to-lymphocyte ratio (P = 0.02), and hemoglobin (P < 0.001), albumin (P < 0.001). In a multivariate analysis, the RDW was an independent prognostic factor for OS (HR = 1.755, 95% CI 1.311-2.349, P < 0.001). CONCLUSIONS: Elevated RDW may be regarded as an indicator of systemic inflammatory response which might facilitate HC growth and metastasis. Current evidence suggests that RDW may have clinical significance in predicting OS after surgery in HC patients. Impact Journals LLC 2017-11-25 /pmc/articles/PMC5752534/ /pubmed/29312621 http://dx.doi.org/10.18632/oncotarget.22694 Text en Copyright: © 2017 Li et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Li, Bei
You, Zhen
Xiong, Xian-Ze
Zhou, Yong
Wu, Si-Jia
Zhou, Rong-Xing
Lu, Jiong
Cheng, Nan-Sheng
Elevated red blood cell distribution width predicts poor prognosis in hilar cholangiocarcinoma
title Elevated red blood cell distribution width predicts poor prognosis in hilar cholangiocarcinoma
title_full Elevated red blood cell distribution width predicts poor prognosis in hilar cholangiocarcinoma
title_fullStr Elevated red blood cell distribution width predicts poor prognosis in hilar cholangiocarcinoma
title_full_unstemmed Elevated red blood cell distribution width predicts poor prognosis in hilar cholangiocarcinoma
title_short Elevated red blood cell distribution width predicts poor prognosis in hilar cholangiocarcinoma
title_sort elevated red blood cell distribution width predicts poor prognosis in hilar cholangiocarcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752534/
https://www.ncbi.nlm.nih.gov/pubmed/29312621
http://dx.doi.org/10.18632/oncotarget.22694
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