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Childhood psychosocial adversity and female reproductive timing: a cohort study of the ALSPAC mothers

BACKGROUND: Previous studies of childhood psychosocial adversity and age at menarche mostly evaluated single or a few measures of adversity, and therefore could not quantify total psychosocial adversity. Limited knowledge is currently available regarding childhood psychosocial adversity in relation...

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Autores principales: Magnus, Maria C, Anderson, Emma L, Howe, Laura D, Joinson, Carol J, Penton-Voak, Ian S, Fraser, Abigail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753025/
https://www.ncbi.nlm.nih.gov/pubmed/29122994
http://dx.doi.org/10.1136/jech-2017-209488
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author Magnus, Maria C
Anderson, Emma L
Howe, Laura D
Joinson, Carol J
Penton-Voak, Ian S
Fraser, Abigail
author_facet Magnus, Maria C
Anderson, Emma L
Howe, Laura D
Joinson, Carol J
Penton-Voak, Ian S
Fraser, Abigail
author_sort Magnus, Maria C
collection PubMed
description BACKGROUND: Previous studies of childhood psychosocial adversity and age at menarche mostly evaluated single or a few measures of adversity, and therefore could not quantify total psychosocial adversity. Limited knowledge is currently available regarding childhood psychosocial adversity in relation to age at menopause and reproductive lifespan. METHODS: We examined the associations of total and specific components of childhood psychosocial adversity with age at menarche (n=8984), age at menopause (n=945), and length of reproductive lifespan (n=841), in mothers participating in the Avon Longitudinal Study of Parents and Children. We used confirmatory factor analysis to characterise lack of care, maladaptive family functioning, non-sexual abuse, overprotective parenting, parental mental illness and sexual abuse. These specific components of childhood psychosocial adversity were combined into a total psychosocial adversity score using a second-order factor analysis. We used structural equation models to simultaneously conduct the factor analysis and estimate the association with the continuous outcomes of interest. RESULTS: Total childhood psychosocial adversity was not associated with age at menarche, age at menopause or length of reproductive lifespan. When we examined the separate psychosocial adversity constructs, sexual abuse was inversely associated with age at menarche, with a mean difference of −0.17 (95% CI −0.23 to −0.12) years per SD higher factor score, and with age at menopause, with a mean difference of −0.17 (95% CI −0.52 to 0.18) per SD higher factor score. CONCLUSION: Childhood sexual abuse was associated with lower age at menarche and menopause, but the latter needs to be confirmed in larger samples.
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spelling pubmed-57530252018-02-12 Childhood psychosocial adversity and female reproductive timing: a cohort study of the ALSPAC mothers Magnus, Maria C Anderson, Emma L Howe, Laura D Joinson, Carol J Penton-Voak, Ian S Fraser, Abigail J Epidemiol Community Health Child Health BACKGROUND: Previous studies of childhood psychosocial adversity and age at menarche mostly evaluated single or a few measures of adversity, and therefore could not quantify total psychosocial adversity. Limited knowledge is currently available regarding childhood psychosocial adversity in relation to age at menopause and reproductive lifespan. METHODS: We examined the associations of total and specific components of childhood psychosocial adversity with age at menarche (n=8984), age at menopause (n=945), and length of reproductive lifespan (n=841), in mothers participating in the Avon Longitudinal Study of Parents and Children. We used confirmatory factor analysis to characterise lack of care, maladaptive family functioning, non-sexual abuse, overprotective parenting, parental mental illness and sexual abuse. These specific components of childhood psychosocial adversity were combined into a total psychosocial adversity score using a second-order factor analysis. We used structural equation models to simultaneously conduct the factor analysis and estimate the association with the continuous outcomes of interest. RESULTS: Total childhood psychosocial adversity was not associated with age at menarche, age at menopause or length of reproductive lifespan. When we examined the separate psychosocial adversity constructs, sexual abuse was inversely associated with age at menarche, with a mean difference of −0.17 (95% CI −0.23 to −0.12) years per SD higher factor score, and with age at menopause, with a mean difference of −0.17 (95% CI −0.52 to 0.18) per SD higher factor score. CONCLUSION: Childhood sexual abuse was associated with lower age at menarche and menopause, but the latter needs to be confirmed in larger samples. BMJ Publishing Group 2018-01 2017-11-09 /pmc/articles/PMC5753025/ /pubmed/29122994 http://dx.doi.org/10.1136/jech-2017-209488 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/
spellingShingle Child Health
Magnus, Maria C
Anderson, Emma L
Howe, Laura D
Joinson, Carol J
Penton-Voak, Ian S
Fraser, Abigail
Childhood psychosocial adversity and female reproductive timing: a cohort study of the ALSPAC mothers
title Childhood psychosocial adversity and female reproductive timing: a cohort study of the ALSPAC mothers
title_full Childhood psychosocial adversity and female reproductive timing: a cohort study of the ALSPAC mothers
title_fullStr Childhood psychosocial adversity and female reproductive timing: a cohort study of the ALSPAC mothers
title_full_unstemmed Childhood psychosocial adversity and female reproductive timing: a cohort study of the ALSPAC mothers
title_short Childhood psychosocial adversity and female reproductive timing: a cohort study of the ALSPAC mothers
title_sort childhood psychosocial adversity and female reproductive timing: a cohort study of the alspac mothers
topic Child Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753025/
https://www.ncbi.nlm.nih.gov/pubmed/29122994
http://dx.doi.org/10.1136/jech-2017-209488
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