DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV‐1 infection of macrophages

We report that DNA damage induced by topoisomerase inhibitors, including etoposide (ETO), results in a potent block to HIV‐1 infection in human monocyte‐derived macrophages (MDM). SAMHD1 suppresses viral reverse transcription (RT) through depletion of cellular dNTPs but is naturally switched off by...

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Detalles Bibliográficos
Autores principales: Mlcochova, Petra, Caswell, Sarah J, Taylor, Ian A, Towers, Greg J, Gupta, Ravindra K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753034/
https://www.ncbi.nlm.nih.gov/pubmed/29084722
http://dx.doi.org/10.15252/embj.201796880

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