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Chronic Pulmonary Aspergillosis—Where Are We? and Where Are We Going?
Chronic pulmonary aspergillosis (CPA) is estimated to affect 3 million people worldwide making it an under recognised, but significant health problem across the globe, conferring significant morbidity and mortality. With variable disease forms, high levels of associated respiratory co-morbidity, lim...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753080/ https://www.ncbi.nlm.nih.gov/pubmed/29376935 http://dx.doi.org/10.3390/jof2020018 |
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author | Hayes, Gemma E. Novak-Frazer, Lilyann |
author_facet | Hayes, Gemma E. Novak-Frazer, Lilyann |
author_sort | Hayes, Gemma E. |
collection | PubMed |
description | Chronic pulmonary aspergillosis (CPA) is estimated to affect 3 million people worldwide making it an under recognised, but significant health problem across the globe, conferring significant morbidity and mortality. With variable disease forms, high levels of associated respiratory co-morbidity, limited therapeutic options and prolonged treatment strategies, CPA is a challenging disease for both patients and healthcare professionals. CPA can mimic smear-negative tuberculosis (TB), pulmonary histoplasmosis or coccidioidomycosis. Cultures for Aspergillus are usually negative, however, the detection of Aspergillus IgG is a simple and sensitive test widely used in diagnosis. When a fungal ball/aspergilloma is visible radiologically, the diagnosis has been made late. Sometimes weight loss and fatigue are predominant symptoms; pyrexia is rare. Despite the efforts of the mycology community, and significant strides being taken in optimising the care of these patients, much remains to be learnt about this patient population, the disease itself and the best use of available therapies, with the development of new therapies being a key priority. Here, current knowledge and practices are reviewed, and areas of research priority highlighted. |
format | Online Article Text |
id | pubmed-5753080 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57530802018-01-19 Chronic Pulmonary Aspergillosis—Where Are We? and Where Are We Going? Hayes, Gemma E. Novak-Frazer, Lilyann J Fungi (Basel) Review Chronic pulmonary aspergillosis (CPA) is estimated to affect 3 million people worldwide making it an under recognised, but significant health problem across the globe, conferring significant morbidity and mortality. With variable disease forms, high levels of associated respiratory co-morbidity, limited therapeutic options and prolonged treatment strategies, CPA is a challenging disease for both patients and healthcare professionals. CPA can mimic smear-negative tuberculosis (TB), pulmonary histoplasmosis or coccidioidomycosis. Cultures for Aspergillus are usually negative, however, the detection of Aspergillus IgG is a simple and sensitive test widely used in diagnosis. When a fungal ball/aspergilloma is visible radiologically, the diagnosis has been made late. Sometimes weight loss and fatigue are predominant symptoms; pyrexia is rare. Despite the efforts of the mycology community, and significant strides being taken in optimising the care of these patients, much remains to be learnt about this patient population, the disease itself and the best use of available therapies, with the development of new therapies being a key priority. Here, current knowledge and practices are reviewed, and areas of research priority highlighted. MDPI 2016-06-07 /pmc/articles/PMC5753080/ /pubmed/29376935 http://dx.doi.org/10.3390/jof2020018 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hayes, Gemma E. Novak-Frazer, Lilyann Chronic Pulmonary Aspergillosis—Where Are We? and Where Are We Going? |
title | Chronic Pulmonary Aspergillosis—Where Are We? and Where Are We Going? |
title_full | Chronic Pulmonary Aspergillosis—Where Are We? and Where Are We Going? |
title_fullStr | Chronic Pulmonary Aspergillosis—Where Are We? and Where Are We Going? |
title_full_unstemmed | Chronic Pulmonary Aspergillosis—Where Are We? and Where Are We Going? |
title_short | Chronic Pulmonary Aspergillosis—Where Are We? and Where Are We Going? |
title_sort | chronic pulmonary aspergillosis—where are we? and where are we going? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753080/ https://www.ncbi.nlm.nih.gov/pubmed/29376935 http://dx.doi.org/10.3390/jof2020018 |
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