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Efinaconazole Topical Solution, 10%: Factors Contributing to Onychomycosis Success

To provide an adequate therapeutic effect against onychomycosis, it has been suggested that topical drugs should have two properties: drug permeability through the nail plate and into the nail bed, and retention of their antifungal activity in the disease-affected areas. Only recently has the import...

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Detalles Bibliográficos
Autores principales: Pollak, Richard A., Jo Siu, William J., Tatsumi, Yoshiyuki, Pillai, Radhakrishnan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753103/
https://www.ncbi.nlm.nih.gov/pubmed/29376902
http://dx.doi.org/10.3390/jof1020107
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author Pollak, Richard A.
Jo Siu, William J.
Tatsumi, Yoshiyuki
Pillai, Radhakrishnan
author_facet Pollak, Richard A.
Jo Siu, William J.
Tatsumi, Yoshiyuki
Pillai, Radhakrishnan
author_sort Pollak, Richard A.
collection PubMed
description To provide an adequate therapeutic effect against onychomycosis, it has been suggested that topical drugs should have two properties: drug permeability through the nail plate and into the nail bed, and retention of their antifungal activity in the disease-affected areas. Only recently has the importance of other delivery routes (such as subungual) been discussed. Efinaconazole has been shown to have a more potent antifungal activity in vitro than the most commonly used onychomycosis treatments. The low keratin affinity of efinaconazole contributes to its effective delivery through the nail plate and retention of its antifungal activity. Its unique low surface tension formulation provides good wetting properties affording drug delivery both through and under the nail. High antifungal drug concentrations have been demonstrated in the nail of onychomycosis patients, and effectiveness of efinaconazole topical solution, 10% confirmed in two large well-controlled multicenter Phase 3 clinical studies in patients with mild-to-moderate disease.
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spelling pubmed-57531032018-01-19 Efinaconazole Topical Solution, 10%: Factors Contributing to Onychomycosis Success Pollak, Richard A. Jo Siu, William J. Tatsumi, Yoshiyuki Pillai, Radhakrishnan J Fungi (Basel) Review To provide an adequate therapeutic effect against onychomycosis, it has been suggested that topical drugs should have two properties: drug permeability through the nail plate and into the nail bed, and retention of their antifungal activity in the disease-affected areas. Only recently has the importance of other delivery routes (such as subungual) been discussed. Efinaconazole has been shown to have a more potent antifungal activity in vitro than the most commonly used onychomycosis treatments. The low keratin affinity of efinaconazole contributes to its effective delivery through the nail plate and retention of its antifungal activity. Its unique low surface tension formulation provides good wetting properties affording drug delivery both through and under the nail. High antifungal drug concentrations have been demonstrated in the nail of onychomycosis patients, and effectiveness of efinaconazole topical solution, 10% confirmed in two large well-controlled multicenter Phase 3 clinical studies in patients with mild-to-moderate disease. MDPI 2015-07-03 /pmc/articles/PMC5753103/ /pubmed/29376902 http://dx.doi.org/10.3390/jof1020107 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pollak, Richard A.
Jo Siu, William J.
Tatsumi, Yoshiyuki
Pillai, Radhakrishnan
Efinaconazole Topical Solution, 10%: Factors Contributing to Onychomycosis Success
title Efinaconazole Topical Solution, 10%: Factors Contributing to Onychomycosis Success
title_full Efinaconazole Topical Solution, 10%: Factors Contributing to Onychomycosis Success
title_fullStr Efinaconazole Topical Solution, 10%: Factors Contributing to Onychomycosis Success
title_full_unstemmed Efinaconazole Topical Solution, 10%: Factors Contributing to Onychomycosis Success
title_short Efinaconazole Topical Solution, 10%: Factors Contributing to Onychomycosis Success
title_sort efinaconazole topical solution, 10%: factors contributing to onychomycosis success
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753103/
https://www.ncbi.nlm.nih.gov/pubmed/29376902
http://dx.doi.org/10.3390/jof1020107
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