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Efinaconazole Topical Solution, 10%: Factors Contributing to Onychomycosis Success
To provide an adequate therapeutic effect against onychomycosis, it has been suggested that topical drugs should have two properties: drug permeability through the nail plate and into the nail bed, and retention of their antifungal activity in the disease-affected areas. Only recently has the import...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753103/ https://www.ncbi.nlm.nih.gov/pubmed/29376902 http://dx.doi.org/10.3390/jof1020107 |
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author | Pollak, Richard A. Jo Siu, William J. Tatsumi, Yoshiyuki Pillai, Radhakrishnan |
author_facet | Pollak, Richard A. Jo Siu, William J. Tatsumi, Yoshiyuki Pillai, Radhakrishnan |
author_sort | Pollak, Richard A. |
collection | PubMed |
description | To provide an adequate therapeutic effect against onychomycosis, it has been suggested that topical drugs should have two properties: drug permeability through the nail plate and into the nail bed, and retention of their antifungal activity in the disease-affected areas. Only recently has the importance of other delivery routes (such as subungual) been discussed. Efinaconazole has been shown to have a more potent antifungal activity in vitro than the most commonly used onychomycosis treatments. The low keratin affinity of efinaconazole contributes to its effective delivery through the nail plate and retention of its antifungal activity. Its unique low surface tension formulation provides good wetting properties affording drug delivery both through and under the nail. High antifungal drug concentrations have been demonstrated in the nail of onychomycosis patients, and effectiveness of efinaconazole topical solution, 10% confirmed in two large well-controlled multicenter Phase 3 clinical studies in patients with mild-to-moderate disease. |
format | Online Article Text |
id | pubmed-5753103 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57531032018-01-19 Efinaconazole Topical Solution, 10%: Factors Contributing to Onychomycosis Success Pollak, Richard A. Jo Siu, William J. Tatsumi, Yoshiyuki Pillai, Radhakrishnan J Fungi (Basel) Review To provide an adequate therapeutic effect against onychomycosis, it has been suggested that topical drugs should have two properties: drug permeability through the nail plate and into the nail bed, and retention of their antifungal activity in the disease-affected areas. Only recently has the importance of other delivery routes (such as subungual) been discussed. Efinaconazole has been shown to have a more potent antifungal activity in vitro than the most commonly used onychomycosis treatments. The low keratin affinity of efinaconazole contributes to its effective delivery through the nail plate and retention of its antifungal activity. Its unique low surface tension formulation provides good wetting properties affording drug delivery both through and under the nail. High antifungal drug concentrations have been demonstrated in the nail of onychomycosis patients, and effectiveness of efinaconazole topical solution, 10% confirmed in two large well-controlled multicenter Phase 3 clinical studies in patients with mild-to-moderate disease. MDPI 2015-07-03 /pmc/articles/PMC5753103/ /pubmed/29376902 http://dx.doi.org/10.3390/jof1020107 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pollak, Richard A. Jo Siu, William J. Tatsumi, Yoshiyuki Pillai, Radhakrishnan Efinaconazole Topical Solution, 10%: Factors Contributing to Onychomycosis Success |
title | Efinaconazole Topical Solution, 10%: Factors Contributing to Onychomycosis Success |
title_full | Efinaconazole Topical Solution, 10%: Factors Contributing to Onychomycosis Success |
title_fullStr | Efinaconazole Topical Solution, 10%: Factors Contributing to Onychomycosis Success |
title_full_unstemmed | Efinaconazole Topical Solution, 10%: Factors Contributing to Onychomycosis Success |
title_short | Efinaconazole Topical Solution, 10%: Factors Contributing to Onychomycosis Success |
title_sort | efinaconazole topical solution, 10%: factors contributing to onychomycosis success |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753103/ https://www.ncbi.nlm.nih.gov/pubmed/29376902 http://dx.doi.org/10.3390/jof1020107 |
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