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Cryptococcus: Shedding New Light on an Inveterate Yeast

Cryptococcus has emerged as a significant pathogen in immunocompromised patients. While the diagnostic testing and the antifungal treatment of cryptococcal infections have become firmly established in clinical practice, new developments and areas of ambiguity merit further consideration. These inclu...

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Detalles Bibliográficos
Autores principales: Haidar, Ghady, Singh, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753104/
https://www.ncbi.nlm.nih.gov/pubmed/29376903
http://dx.doi.org/10.3390/jof1020115
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author Haidar, Ghady
Singh, Nina
author_facet Haidar, Ghady
Singh, Nina
author_sort Haidar, Ghady
collection PubMed
description Cryptococcus has emerged as a significant pathogen in immunocompromised patients. While the diagnostic testing and the antifungal treatment of cryptococcal infections have become firmly established in clinical practice, new developments and areas of ambiguity merit further consideration. These include the potential for donor transmission of Cryptococcus; cirrhosis-associated cryptococcosis, particularly during transplant candidacy; the utility of serum cryptococcal antigen testing of asymptomatic individuals in high-prevalence, poor-resource areas; pathogenesis and treatment of the immune reconstitution syndrome, specifically in relation to antiretroviral therapy and immunosuppressive medications; and new challenges posed by the emerging species of Cryptococcus gatti. In this article, we summarize the literature pertaining to these topics, focusing on recent progress.
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spelling pubmed-57531042018-01-19 Cryptococcus: Shedding New Light on an Inveterate Yeast Haidar, Ghady Singh, Nina J Fungi (Basel) Review Cryptococcus has emerged as a significant pathogen in immunocompromised patients. While the diagnostic testing and the antifungal treatment of cryptococcal infections have become firmly established in clinical practice, new developments and areas of ambiguity merit further consideration. These include the potential for donor transmission of Cryptococcus; cirrhosis-associated cryptococcosis, particularly during transplant candidacy; the utility of serum cryptococcal antigen testing of asymptomatic individuals in high-prevalence, poor-resource areas; pathogenesis and treatment of the immune reconstitution syndrome, specifically in relation to antiretroviral therapy and immunosuppressive medications; and new challenges posed by the emerging species of Cryptococcus gatti. In this article, we summarize the literature pertaining to these topics, focusing on recent progress. MDPI 2015-07-14 /pmc/articles/PMC5753104/ /pubmed/29376903 http://dx.doi.org/10.3390/jof1020115 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Haidar, Ghady
Singh, Nina
Cryptococcus: Shedding New Light on an Inveterate Yeast
title Cryptococcus: Shedding New Light on an Inveterate Yeast
title_full Cryptococcus: Shedding New Light on an Inveterate Yeast
title_fullStr Cryptococcus: Shedding New Light on an Inveterate Yeast
title_full_unstemmed Cryptococcus: Shedding New Light on an Inveterate Yeast
title_short Cryptococcus: Shedding New Light on an Inveterate Yeast
title_sort cryptococcus: shedding new light on an inveterate yeast
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753104/
https://www.ncbi.nlm.nih.gov/pubmed/29376903
http://dx.doi.org/10.3390/jof1020115
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