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Cryptococcus: Shedding New Light on an Inveterate Yeast
Cryptococcus has emerged as a significant pathogen in immunocompromised patients. While the diagnostic testing and the antifungal treatment of cryptococcal infections have become firmly established in clinical practice, new developments and areas of ambiguity merit further consideration. These inclu...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753104/ https://www.ncbi.nlm.nih.gov/pubmed/29376903 http://dx.doi.org/10.3390/jof1020115 |
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author | Haidar, Ghady Singh, Nina |
author_facet | Haidar, Ghady Singh, Nina |
author_sort | Haidar, Ghady |
collection | PubMed |
description | Cryptococcus has emerged as a significant pathogen in immunocompromised patients. While the diagnostic testing and the antifungal treatment of cryptococcal infections have become firmly established in clinical practice, new developments and areas of ambiguity merit further consideration. These include the potential for donor transmission of Cryptococcus; cirrhosis-associated cryptococcosis, particularly during transplant candidacy; the utility of serum cryptococcal antigen testing of asymptomatic individuals in high-prevalence, poor-resource areas; pathogenesis and treatment of the immune reconstitution syndrome, specifically in relation to antiretroviral therapy and immunosuppressive medications; and new challenges posed by the emerging species of Cryptococcus gatti. In this article, we summarize the literature pertaining to these topics, focusing on recent progress. |
format | Online Article Text |
id | pubmed-5753104 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57531042018-01-19 Cryptococcus: Shedding New Light on an Inveterate Yeast Haidar, Ghady Singh, Nina J Fungi (Basel) Review Cryptococcus has emerged as a significant pathogen in immunocompromised patients. While the diagnostic testing and the antifungal treatment of cryptococcal infections have become firmly established in clinical practice, new developments and areas of ambiguity merit further consideration. These include the potential for donor transmission of Cryptococcus; cirrhosis-associated cryptococcosis, particularly during transplant candidacy; the utility of serum cryptococcal antigen testing of asymptomatic individuals in high-prevalence, poor-resource areas; pathogenesis and treatment of the immune reconstitution syndrome, specifically in relation to antiretroviral therapy and immunosuppressive medications; and new challenges posed by the emerging species of Cryptococcus gatti. In this article, we summarize the literature pertaining to these topics, focusing on recent progress. MDPI 2015-07-14 /pmc/articles/PMC5753104/ /pubmed/29376903 http://dx.doi.org/10.3390/jof1020115 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Haidar, Ghady Singh, Nina Cryptococcus: Shedding New Light on an Inveterate Yeast |
title | Cryptococcus: Shedding New Light on an Inveterate Yeast |
title_full | Cryptococcus: Shedding New Light on an Inveterate Yeast |
title_fullStr | Cryptococcus: Shedding New Light on an Inveterate Yeast |
title_full_unstemmed | Cryptococcus: Shedding New Light on an Inveterate Yeast |
title_short | Cryptococcus: Shedding New Light on an Inveterate Yeast |
title_sort | cryptococcus: shedding new light on an inveterate yeast |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753104/ https://www.ncbi.nlm.nih.gov/pubmed/29376903 http://dx.doi.org/10.3390/jof1020115 |
work_keys_str_mv | AT haidarghady cryptococcussheddingnewlightonaninveterateyeast AT singhnina cryptococcussheddingnewlightonaninveterateyeast |