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Pneumocystis Pneumonia in Solid-Organ Transplant Recipients

Pneumocystis pneumonia (PCP) is well known and described in AIDS patients. Due to the increasing use of cytotoxic and immunosuppressive therapies, the incidence of this infection has dramatically increased in the last years in patients with other predisposing immunodeficiencies and remains an import...

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Autores principales: Iriart, Xavier, Le Bouar, Marine, Kamar, Nassim, Berry, Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753127/
https://www.ncbi.nlm.nih.gov/pubmed/29376913
http://dx.doi.org/10.3390/jof1030293
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author Iriart, Xavier
Le Bouar, Marine
Kamar, Nassim
Berry, Antoine
author_facet Iriart, Xavier
Le Bouar, Marine
Kamar, Nassim
Berry, Antoine
author_sort Iriart, Xavier
collection PubMed
description Pneumocystis pneumonia (PCP) is well known and described in AIDS patients. Due to the increasing use of cytotoxic and immunosuppressive therapies, the incidence of this infection has dramatically increased in the last years in patients with other predisposing immunodeficiencies and remains an important cause of morbidity and mortality in solid-organ transplant (SOT) recipients. PCP in HIV-negative patients, such as SOT patients, harbors some specificity compared to AIDS patients, which could change the medical management of these patients. This article summarizes the current knowledge on the epidemiology, risk factors, clinical manifestations, diagnoses, prevention, and treatment of Pneumocystis pneumonia in solid-organ transplant recipients, with a particular focus on the changes caused by the use of post-transplantation prophylaxis.
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spelling pubmed-57531272018-01-19 Pneumocystis Pneumonia in Solid-Organ Transplant Recipients Iriart, Xavier Le Bouar, Marine Kamar, Nassim Berry, Antoine J Fungi (Basel) Review Pneumocystis pneumonia (PCP) is well known and described in AIDS patients. Due to the increasing use of cytotoxic and immunosuppressive therapies, the incidence of this infection has dramatically increased in the last years in patients with other predisposing immunodeficiencies and remains an important cause of morbidity and mortality in solid-organ transplant (SOT) recipients. PCP in HIV-negative patients, such as SOT patients, harbors some specificity compared to AIDS patients, which could change the medical management of these patients. This article summarizes the current knowledge on the epidemiology, risk factors, clinical manifestations, diagnoses, prevention, and treatment of Pneumocystis pneumonia in solid-organ transplant recipients, with a particular focus on the changes caused by the use of post-transplantation prophylaxis. MDPI 2015-09-28 /pmc/articles/PMC5753127/ /pubmed/29376913 http://dx.doi.org/10.3390/jof1030293 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Iriart, Xavier
Le Bouar, Marine
Kamar, Nassim
Berry, Antoine
Pneumocystis Pneumonia in Solid-Organ Transplant Recipients
title Pneumocystis Pneumonia in Solid-Organ Transplant Recipients
title_full Pneumocystis Pneumonia in Solid-Organ Transplant Recipients
title_fullStr Pneumocystis Pneumonia in Solid-Organ Transplant Recipients
title_full_unstemmed Pneumocystis Pneumonia in Solid-Organ Transplant Recipients
title_short Pneumocystis Pneumonia in Solid-Organ Transplant Recipients
title_sort pneumocystis pneumonia in solid-organ transplant recipients
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753127/
https://www.ncbi.nlm.nih.gov/pubmed/29376913
http://dx.doi.org/10.3390/jof1030293
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