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Pneumocystis Pneumonia in Solid-Organ Transplant Recipients
Pneumocystis pneumonia (PCP) is well known and described in AIDS patients. Due to the increasing use of cytotoxic and immunosuppressive therapies, the incidence of this infection has dramatically increased in the last years in patients with other predisposing immunodeficiencies and remains an import...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753127/ https://www.ncbi.nlm.nih.gov/pubmed/29376913 http://dx.doi.org/10.3390/jof1030293 |
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author | Iriart, Xavier Le Bouar, Marine Kamar, Nassim Berry, Antoine |
author_facet | Iriart, Xavier Le Bouar, Marine Kamar, Nassim Berry, Antoine |
author_sort | Iriart, Xavier |
collection | PubMed |
description | Pneumocystis pneumonia (PCP) is well known and described in AIDS patients. Due to the increasing use of cytotoxic and immunosuppressive therapies, the incidence of this infection has dramatically increased in the last years in patients with other predisposing immunodeficiencies and remains an important cause of morbidity and mortality in solid-organ transplant (SOT) recipients. PCP in HIV-negative patients, such as SOT patients, harbors some specificity compared to AIDS patients, which could change the medical management of these patients. This article summarizes the current knowledge on the epidemiology, risk factors, clinical manifestations, diagnoses, prevention, and treatment of Pneumocystis pneumonia in solid-organ transplant recipients, with a particular focus on the changes caused by the use of post-transplantation prophylaxis. |
format | Online Article Text |
id | pubmed-5753127 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57531272018-01-19 Pneumocystis Pneumonia in Solid-Organ Transplant Recipients Iriart, Xavier Le Bouar, Marine Kamar, Nassim Berry, Antoine J Fungi (Basel) Review Pneumocystis pneumonia (PCP) is well known and described in AIDS patients. Due to the increasing use of cytotoxic and immunosuppressive therapies, the incidence of this infection has dramatically increased in the last years in patients with other predisposing immunodeficiencies and remains an important cause of morbidity and mortality in solid-organ transplant (SOT) recipients. PCP in HIV-negative patients, such as SOT patients, harbors some specificity compared to AIDS patients, which could change the medical management of these patients. This article summarizes the current knowledge on the epidemiology, risk factors, clinical manifestations, diagnoses, prevention, and treatment of Pneumocystis pneumonia in solid-organ transplant recipients, with a particular focus on the changes caused by the use of post-transplantation prophylaxis. MDPI 2015-09-28 /pmc/articles/PMC5753127/ /pubmed/29376913 http://dx.doi.org/10.3390/jof1030293 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Iriart, Xavier Le Bouar, Marine Kamar, Nassim Berry, Antoine Pneumocystis Pneumonia in Solid-Organ Transplant Recipients |
title | Pneumocystis Pneumonia in Solid-Organ Transplant Recipients |
title_full | Pneumocystis Pneumonia in Solid-Organ Transplant Recipients |
title_fullStr | Pneumocystis Pneumonia in Solid-Organ Transplant Recipients |
title_full_unstemmed | Pneumocystis Pneumonia in Solid-Organ Transplant Recipients |
title_short | Pneumocystis Pneumonia in Solid-Organ Transplant Recipients |
title_sort | pneumocystis pneumonia in solid-organ transplant recipients |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753127/ https://www.ncbi.nlm.nih.gov/pubmed/29376913 http://dx.doi.org/10.3390/jof1030293 |
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