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Triazole Resistance in Aspergillus spp.: A Worldwide Problem?
Since the first description of an azole-resistant A. fumigatus strain in 1997, there has been an increasing number of papers describing the emergence of azole resistance. Firstly reported in the USA and soon after in Europe, it has now been described worldwide, challenging the management of human as...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753134/ https://www.ncbi.nlm.nih.gov/pubmed/29376938 http://dx.doi.org/10.3390/jof2030021 |
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author | Rivero-Menendez, Olga Alastruey-Izquierdo, Ana Mellado, Emilia Cuenca-Estrella, Manuel |
author_facet | Rivero-Menendez, Olga Alastruey-Izquierdo, Ana Mellado, Emilia Cuenca-Estrella, Manuel |
author_sort | Rivero-Menendez, Olga |
collection | PubMed |
description | Since the first description of an azole-resistant A. fumigatus strain in 1997, there has been an increasing number of papers describing the emergence of azole resistance. Firstly reported in the USA and soon after in Europe, it has now been described worldwide, challenging the management of human aspergillosis. The main mechanism of resistance is the modification of the azole target enzyme: 14-α sterol demethylase, encoded by the cyp51A gene; although recently, other resistance mechanisms have also been implicated. In addition, a shift in the epidemiology has been noted with other Aspergillus species (mostly azole resistant) increasingly being reported as causative agents of human disease. This paper reviews the current situation of Aspergillus azole resistance and its implications in the clinical setting. |
format | Online Article Text |
id | pubmed-5753134 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57531342018-01-19 Triazole Resistance in Aspergillus spp.: A Worldwide Problem? Rivero-Menendez, Olga Alastruey-Izquierdo, Ana Mellado, Emilia Cuenca-Estrella, Manuel J Fungi (Basel) Review Since the first description of an azole-resistant A. fumigatus strain in 1997, there has been an increasing number of papers describing the emergence of azole resistance. Firstly reported in the USA and soon after in Europe, it has now been described worldwide, challenging the management of human aspergillosis. The main mechanism of resistance is the modification of the azole target enzyme: 14-α sterol demethylase, encoded by the cyp51A gene; although recently, other resistance mechanisms have also been implicated. In addition, a shift in the epidemiology has been noted with other Aspergillus species (mostly azole resistant) increasingly being reported as causative agents of human disease. This paper reviews the current situation of Aspergillus azole resistance and its implications in the clinical setting. MDPI 2016-07-04 /pmc/articles/PMC5753134/ /pubmed/29376938 http://dx.doi.org/10.3390/jof2030021 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rivero-Menendez, Olga Alastruey-Izquierdo, Ana Mellado, Emilia Cuenca-Estrella, Manuel Triazole Resistance in Aspergillus spp.: A Worldwide Problem? |
title | Triazole Resistance in Aspergillus spp.: A Worldwide Problem? |
title_full | Triazole Resistance in Aspergillus spp.: A Worldwide Problem? |
title_fullStr | Triazole Resistance in Aspergillus spp.: A Worldwide Problem? |
title_full_unstemmed | Triazole Resistance in Aspergillus spp.: A Worldwide Problem? |
title_short | Triazole Resistance in Aspergillus spp.: A Worldwide Problem? |
title_sort | triazole resistance in aspergillus spp.: a worldwide problem? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753134/ https://www.ncbi.nlm.nih.gov/pubmed/29376938 http://dx.doi.org/10.3390/jof2030021 |
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