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Position-dependent impact of hexafluoroleucine and trifluoroisoleucine on protease digestion

Rapid digestion by proteases limits the application of peptides as therapeutics. One strategy to increase the proteolytic stability of peptides is the modification with fluorinated amino acids. This study presents a systematic investigation of the effects of fluorinated leucine and isoleucine deriva...

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Detalles Bibliográficos
Autores principales:	Huhmann, Susanne, Stegemann, Anne-Katrin, Folmert, Kristin, Klemczak, Damian, Moschner, Johann, Kube, Michelle, Koksch, Beate
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2017
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753150/ https://www.ncbi.nlm.nih.gov/pubmed/29564015 http://dx.doi.org/10.3762/bjoc.13.279

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