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Fungal Strategies to Evade the Host Immune Recognition
The recognition of fungal cells by the host immune system is key during the establishment of a protective anti-fungal response. Even though the immune system has evolved a vast number of processes to control these organisms, they have developed strategies to fight back, avoiding the proper recogniti...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753153/ https://www.ncbi.nlm.nih.gov/pubmed/29371567 http://dx.doi.org/10.3390/jof3040051 |
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author | Hernández-Chávez, Marco J. Pérez-García, Luis A. Niño-Vega, Gustavo A. Mora-Montes, Héctor M. |
author_facet | Hernández-Chávez, Marco J. Pérez-García, Luis A. Niño-Vega, Gustavo A. Mora-Montes, Héctor M. |
author_sort | Hernández-Chávez, Marco J. |
collection | PubMed |
description | The recognition of fungal cells by the host immune system is key during the establishment of a protective anti-fungal response. Even though the immune system has evolved a vast number of processes to control these organisms, they have developed strategies to fight back, avoiding the proper recognition by immune components and thus interfering with the host protective mechanisms. Therefore, the strategies to evade the immune system are as important as the virulence factors and attributes that damage the host tissues and cells. Here, we performed a thorough revision of the main fungal tactics to escape from the host immunosurveillance processes. These include the composition and organization of the cell wall, the fungal capsule, the formation of titan cells, biofilms, and asteroid bodies; the ability to undergo dimorphism; and the escape from nutritional immunity, extracellular traps, phagocytosis, and the action of humoral immune effectors. |
format | Online Article Text |
id | pubmed-5753153 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-57531532018-01-19 Fungal Strategies to Evade the Host Immune Recognition Hernández-Chávez, Marco J. Pérez-García, Luis A. Niño-Vega, Gustavo A. Mora-Montes, Héctor M. J Fungi (Basel) Review The recognition of fungal cells by the host immune system is key during the establishment of a protective anti-fungal response. Even though the immune system has evolved a vast number of processes to control these organisms, they have developed strategies to fight back, avoiding the proper recognition by immune components and thus interfering with the host protective mechanisms. Therefore, the strategies to evade the immune system are as important as the virulence factors and attributes that damage the host tissues and cells. Here, we performed a thorough revision of the main fungal tactics to escape from the host immunosurveillance processes. These include the composition and organization of the cell wall, the fungal capsule, the formation of titan cells, biofilms, and asteroid bodies; the ability to undergo dimorphism; and the escape from nutritional immunity, extracellular traps, phagocytosis, and the action of humoral immune effectors. MDPI 2017-09-23 /pmc/articles/PMC5753153/ /pubmed/29371567 http://dx.doi.org/10.3390/jof3040051 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hernández-Chávez, Marco J. Pérez-García, Luis A. Niño-Vega, Gustavo A. Mora-Montes, Héctor M. Fungal Strategies to Evade the Host Immune Recognition |
title | Fungal Strategies to Evade the Host Immune Recognition |
title_full | Fungal Strategies to Evade the Host Immune Recognition |
title_fullStr | Fungal Strategies to Evade the Host Immune Recognition |
title_full_unstemmed | Fungal Strategies to Evade the Host Immune Recognition |
title_short | Fungal Strategies to Evade the Host Immune Recognition |
title_sort | fungal strategies to evade the host immune recognition |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753153/ https://www.ncbi.nlm.nih.gov/pubmed/29371567 http://dx.doi.org/10.3390/jof3040051 |
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