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Global and Multi-National Prevalence of Fungal Diseases—Estimate Precision

Fungal diseases kill more than 1.5 million and affect over a billion people. However, they are still a neglected topic by public health authorities even though most deaths from fungal diseases are avoidable. Serious fungal infections occur as a consequence of other health problems including asthma,...

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Autores principales: Bongomin, Felix, Gago, Sara, Oladele, Rita O., Denning, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753159/
https://www.ncbi.nlm.nih.gov/pubmed/29371573
http://dx.doi.org/10.3390/jof3040057
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author Bongomin, Felix
Gago, Sara
Oladele, Rita O.
Denning, David W.
author_facet Bongomin, Felix
Gago, Sara
Oladele, Rita O.
Denning, David W.
author_sort Bongomin, Felix
collection PubMed
description Fungal diseases kill more than 1.5 million and affect over a billion people. However, they are still a neglected topic by public health authorities even though most deaths from fungal diseases are avoidable. Serious fungal infections occur as a consequence of other health problems including asthma, AIDS, cancer, organ transplantation and corticosteroid therapies. Early accurate diagnosis allows prompt antifungal therapy; however this is often delayed or unavailable leading to death, serious chronic illness or blindness. Recent global estimates have found 3,000,000 cases of chronic pulmonary aspergillosis, ~223,100 cases of cryptococcal meningitis complicating HIV/AIDS, ~700,000 cases of invasive candidiasis, ~500,000 cases of Pneumocystis jirovecii pneumonia, ~250,000 cases of invasive aspergillosis, ~100,000 cases of disseminated histoplasmosis, over 10,000,000 cases of fungal asthma and ~1,000,000 cases of fungal keratitis occur annually. Since 2013, the Leading International Fungal Education (LIFE) portal has facilitated the estimation of the burden of serious fungal infections country by country for over 5.7 billion people (>80% of the world’s population). These studies have shown differences in the global burden between countries, within regions of the same country and between at risk populations. Here we interrogate the accuracy of these fungal infection burden estimates in the 43 published papers within the LIFE initiative.
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spelling pubmed-57531592018-01-19 Global and Multi-National Prevalence of Fungal Diseases—Estimate Precision Bongomin, Felix Gago, Sara Oladele, Rita O. Denning, David W. J Fungi (Basel) Review Fungal diseases kill more than 1.5 million and affect over a billion people. However, they are still a neglected topic by public health authorities even though most deaths from fungal diseases are avoidable. Serious fungal infections occur as a consequence of other health problems including asthma, AIDS, cancer, organ transplantation and corticosteroid therapies. Early accurate diagnosis allows prompt antifungal therapy; however this is often delayed or unavailable leading to death, serious chronic illness or blindness. Recent global estimates have found 3,000,000 cases of chronic pulmonary aspergillosis, ~223,100 cases of cryptococcal meningitis complicating HIV/AIDS, ~700,000 cases of invasive candidiasis, ~500,000 cases of Pneumocystis jirovecii pneumonia, ~250,000 cases of invasive aspergillosis, ~100,000 cases of disseminated histoplasmosis, over 10,000,000 cases of fungal asthma and ~1,000,000 cases of fungal keratitis occur annually. Since 2013, the Leading International Fungal Education (LIFE) portal has facilitated the estimation of the burden of serious fungal infections country by country for over 5.7 billion people (>80% of the world’s population). These studies have shown differences in the global burden between countries, within regions of the same country and between at risk populations. Here we interrogate the accuracy of these fungal infection burden estimates in the 43 published papers within the LIFE initiative. MDPI 2017-10-18 /pmc/articles/PMC5753159/ /pubmed/29371573 http://dx.doi.org/10.3390/jof3040057 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bongomin, Felix
Gago, Sara
Oladele, Rita O.
Denning, David W.
Global and Multi-National Prevalence of Fungal Diseases—Estimate Precision
title Global and Multi-National Prevalence of Fungal Diseases—Estimate Precision
title_full Global and Multi-National Prevalence of Fungal Diseases—Estimate Precision
title_fullStr Global and Multi-National Prevalence of Fungal Diseases—Estimate Precision
title_full_unstemmed Global and Multi-National Prevalence of Fungal Diseases—Estimate Precision
title_short Global and Multi-National Prevalence of Fungal Diseases—Estimate Precision
title_sort global and multi-national prevalence of fungal diseases—estimate precision
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753159/
https://www.ncbi.nlm.nih.gov/pubmed/29371573
http://dx.doi.org/10.3390/jof3040057
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