Cargando…
STCRDab: the structural T-cell receptor database
The Structural T–cell Receptor Database (STCRDab; http://opig.stats.ox.ac.uk/webapps/stcrdab) is an online resource that automatically collects and curates TCR structural data from the Protein Data Bank. For each entry, the database provides annotations, such as the α/β or γ/δ chain pairings, major...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753249/ https://www.ncbi.nlm.nih.gov/pubmed/29087479 http://dx.doi.org/10.1093/nar/gkx971 |
_version_ | 1783290240370212864 |
---|---|
author | Leem, Jinwoo de Oliveira, Saulo H P Krawczyk, Konrad Deane, Charlotte M |
author_facet | Leem, Jinwoo de Oliveira, Saulo H P Krawczyk, Konrad Deane, Charlotte M |
author_sort | Leem, Jinwoo |
collection | PubMed |
description | The Structural T–cell Receptor Database (STCRDab; http://opig.stats.ox.ac.uk/webapps/stcrdab) is an online resource that automatically collects and curates TCR structural data from the Protein Data Bank. For each entry, the database provides annotations, such as the α/β or γ/δ chain pairings, major histocompatibility complex details, and where available, antigen binding affinities. In addition, the orientation between the variable domains and the canonical forms of the complementarity-determining region loops are also provided. Users can select, view, and download individual or bulk sets of structures based on these criteria. Where available, STCRDab also finds antibody structures that are similar to TCRs, helping users explore the relationship between TCRs and antibodies. |
format | Online Article Text |
id | pubmed-5753249 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-57532492018-01-05 STCRDab: the structural T-cell receptor database Leem, Jinwoo de Oliveira, Saulo H P Krawczyk, Konrad Deane, Charlotte M Nucleic Acids Res Database Issue The Structural T–cell Receptor Database (STCRDab; http://opig.stats.ox.ac.uk/webapps/stcrdab) is an online resource that automatically collects and curates TCR structural data from the Protein Data Bank. For each entry, the database provides annotations, such as the α/β or γ/δ chain pairings, major histocompatibility complex details, and where available, antigen binding affinities. In addition, the orientation between the variable domains and the canonical forms of the complementarity-determining region loops are also provided. Users can select, view, and download individual or bulk sets of structures based on these criteria. Where available, STCRDab also finds antibody structures that are similar to TCRs, helping users explore the relationship between TCRs and antibodies. Oxford University Press 2018-01-04 2017-10-26 /pmc/articles/PMC5753249/ /pubmed/29087479 http://dx.doi.org/10.1093/nar/gkx971 Text en © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Database Issue Leem, Jinwoo de Oliveira, Saulo H P Krawczyk, Konrad Deane, Charlotte M STCRDab: the structural T-cell receptor database |
title | STCRDab: the structural T-cell receptor database |
title_full | STCRDab: the structural T-cell receptor database |
title_fullStr | STCRDab: the structural T-cell receptor database |
title_full_unstemmed | STCRDab: the structural T-cell receptor database |
title_short | STCRDab: the structural T-cell receptor database |
title_sort | stcrdab: the structural t-cell receptor database |
topic | Database Issue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753249/ https://www.ncbi.nlm.nih.gov/pubmed/29087479 http://dx.doi.org/10.1093/nar/gkx971 |
work_keys_str_mv | AT leemjinwoo stcrdabthestructuraltcellreceptordatabase AT deoliveirasaulohp stcrdabthestructuraltcellreceptordatabase AT krawczykkonrad stcrdabthestructuraltcellreceptordatabase AT deanecharlottem stcrdabthestructuraltcellreceptordatabase |