MODOMICS: a database of RNA modification pathways. 2017 update

MODOMICS is a database of RNA modifications that provides comprehensive information concerning the chemical structures of modified ribonucleosides, their biosynthetic pathways, the location of modified residues in RNA sequences, and RNA-modifying enzymes. In the current database version, we included...

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Detalles Bibliográficos
Autores principales: Boccaletto, Pietro, Machnicka, Magdalena A, Purta, Elzbieta, Piątkowski, Paweł, Bagiński, Błażej, Wirecki, Tomasz K, de Crécy-Lagard, Valérie, Ross, Robert, Limbach, Patrick A, Kotter, Annika, Helm, Mark, Bujnicki, Janusz M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Database Issue
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753262/
https://www.ncbi.nlm.nih.gov/pubmed/29106616
http://dx.doi.org/10.1093/nar/gkx1030
Descripción
Sumario:MODOMICS is a database of RNA modifications that provides comprehensive information concerning the chemical structures of modified ribonucleosides, their biosynthetic pathways, the location of modified residues in RNA sequences, and RNA-modifying enzymes. In the current database version, we included the following new features and data: extended mass spectrometry and liquid chromatography data for modified nucleosides; links between human tRNA sequences and MINTbase - a framework for the interactive exploration of mitochondrial and nuclear tRNA fragments; new, machine-friendly system of unified abbreviations for modified nucleoside names; sets of modified tRNA sequences for two bacterial species, updated collection of mammalian tRNA modifications, 19 newly identified modified ribonucleosides and 66 functionally characterized proteins involved in RNA modification. Data from MODOMICS have been linked to the RNAcentral database of RNA sequences. MODOMICS is available at http://modomics.genesilico.pl.

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