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Hair product use, age at menarche and mammographic breast density in multiethnic urban women
BACKGROUND: Select hair products contain endocrine disrupting chemicals (EDCs) that may affect breast cancer risk. We hypothesize that, if EDCs are related to breast cancer risk, then they may also affect two important breast cancer risk factors: age at menarche and mammographic breast density. METH...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753455/ https://www.ncbi.nlm.nih.gov/pubmed/29301538 http://dx.doi.org/10.1186/s12940-017-0345-y |
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author | McDonald, Jasmine A. Tehranifar, Parisa Flom, Julie D. Terry, Mary Beth James-Todd, Tamarra |
author_facet | McDonald, Jasmine A. Tehranifar, Parisa Flom, Julie D. Terry, Mary Beth James-Todd, Tamarra |
author_sort | McDonald, Jasmine A. |
collection | PubMed |
description | BACKGROUND: Select hair products contain endocrine disrupting chemicals (EDCs) that may affect breast cancer risk. We hypothesize that, if EDCs are related to breast cancer risk, then they may also affect two important breast cancer risk factors: age at menarche and mammographic breast density. METHODS: In two urban female cohorts (N = 248): 1) the New York site of the National Collaborative Perinatal Project and 2) the New York City Multiethnic Breast Cancer Project, we measured childhood and adult use of hair oils, lotions, leave-in conditioners, root stimulators, perms/relaxers, and hair dyes using the same validated questionnaire. We used multivariable relative risk regression models to examine the association between childhood hair product use and early age at menarche (defined as <11 years of age) and multivariable linear regression models to examine the association between childhood and adult hair product use and adult mammographic breast density. RESULTS: Early menarche was associated with ever use of childhood hair products (RR 2.3, 95% CI 1.1, 4.8) and hair oil use (RR 2.5, 95% CI 1.2, 5.2); however, additional adjustment for race/ethnicity, attenuated associations (hair products RR 1.8, 95% CI 0.8, 4.1; hair oil use RR 2.3, 95% CI 1.0, 5.5). Breast density was not associated with adult or childhood hair product or hair oil use. CONCLUSIONS: If confirmed in larger prospective studies, these data suggest that exposure to EDCs through hair products in early life may affect breast cancer risk by altering timing of menarche, and may operate through a mechanism distinct from breast density. |
format | Online Article Text |
id | pubmed-5753455 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-57534552018-01-05 Hair product use, age at menarche and mammographic breast density in multiethnic urban women McDonald, Jasmine A. Tehranifar, Parisa Flom, Julie D. Terry, Mary Beth James-Todd, Tamarra Environ Health Research BACKGROUND: Select hair products contain endocrine disrupting chemicals (EDCs) that may affect breast cancer risk. We hypothesize that, if EDCs are related to breast cancer risk, then they may also affect two important breast cancer risk factors: age at menarche and mammographic breast density. METHODS: In two urban female cohorts (N = 248): 1) the New York site of the National Collaborative Perinatal Project and 2) the New York City Multiethnic Breast Cancer Project, we measured childhood and adult use of hair oils, lotions, leave-in conditioners, root stimulators, perms/relaxers, and hair dyes using the same validated questionnaire. We used multivariable relative risk regression models to examine the association between childhood hair product use and early age at menarche (defined as <11 years of age) and multivariable linear regression models to examine the association between childhood and adult hair product use and adult mammographic breast density. RESULTS: Early menarche was associated with ever use of childhood hair products (RR 2.3, 95% CI 1.1, 4.8) and hair oil use (RR 2.5, 95% CI 1.2, 5.2); however, additional adjustment for race/ethnicity, attenuated associations (hair products RR 1.8, 95% CI 0.8, 4.1; hair oil use RR 2.3, 95% CI 1.0, 5.5). Breast density was not associated with adult or childhood hair product or hair oil use. CONCLUSIONS: If confirmed in larger prospective studies, these data suggest that exposure to EDCs through hair products in early life may affect breast cancer risk by altering timing of menarche, and may operate through a mechanism distinct from breast density. BioMed Central 2018-01-04 /pmc/articles/PMC5753455/ /pubmed/29301538 http://dx.doi.org/10.1186/s12940-017-0345-y Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research McDonald, Jasmine A. Tehranifar, Parisa Flom, Julie D. Terry, Mary Beth James-Todd, Tamarra Hair product use, age at menarche and mammographic breast density in multiethnic urban women |
title | Hair product use, age at menarche and mammographic breast density in multiethnic urban women |
title_full | Hair product use, age at menarche and mammographic breast density in multiethnic urban women |
title_fullStr | Hair product use, age at menarche and mammographic breast density in multiethnic urban women |
title_full_unstemmed | Hair product use, age at menarche and mammographic breast density in multiethnic urban women |
title_short | Hair product use, age at menarche and mammographic breast density in multiethnic urban women |
title_sort | hair product use, age at menarche and mammographic breast density in multiethnic urban women |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753455/ https://www.ncbi.nlm.nih.gov/pubmed/29301538 http://dx.doi.org/10.1186/s12940-017-0345-y |
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