Distinct subtypes of genomic PTEN deletion size influence the landscape of aneuploidy and outcome in prostate cancer

BACKGROUND: Inactivation of the PTEN tumor suppressor gene by deletion occurs in 20–30% of prostate cancer tumors and loss strongly correlates with a worse outcome. PTEN loss of function not only leads to activation of the PI3K/AKT pathway, but is also thought to affect genome stability and increase...

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Detalles Bibliográficos
Autores principales: Vidotto, Thiago, Tiezzi, Daniel Guimarães, Squire, Jeremy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753467/
https://www.ncbi.nlm.nih.gov/pubmed/29308088
http://dx.doi.org/10.1186/s13039-017-0348-y

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