Cargando…

Inhibition of cyclin-dependent kinase 5 affects early neuroinflammatory signalling in murine model of amyloid beta toxicity

BACKGROUND: Cyclin-dependent kinase 5 (Cdk5) belongs to the family of proline-directed serine/threonine kinases and plays a critical role in neuronal differentiation, migration, synaptogenesis, plasticity, neurotransmission and apoptosis. The deregulation of Cdk5 activity was observed in post mortem...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wilkaniec, Anna, Gąssowska-Dobrowolska, Magdalena, Strawski, Marcin, Adamczyk, Agata, Czapski, Grzegorz A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753486/ https://www.ncbi.nlm.nih.gov/pubmed/29301548 http://dx.doi.org/10.1186/s12974-017-1027-y

Ejemplares similares

P2X7 receptor-pannexin 1 interaction mediates extracellular alpha-synuclein-induced ATP release in neuroblastoma SH-SY5Y cells
por: Wilkaniec, Anna, et al.
Publicado: (2017)

The Role of Bromodomain and Extraterminal (BET) Proteins in Controlling the Phagocytic Activity of Microglia In Vitro: Relevance to Alzheimer’s Disease
por: Matuszewska, Marta, et al.
Publicado: (2022)

Extracellular Alpha-Synuclein Oligomers Induce Parkin S-Nitrosylation: Relevance to Sporadic Parkinson’s Disease Etiopathology
por: Wilkaniec, Anna, et al.
Publicado: (2018)

Microtubule Cytoskeletal Network Alterations in a Transgenic Model of Tuberous Sclerosis Complex: Relevance to Autism Spectrum Disorders
por: Gąssowska-Dobrowolska, Magdalena, et al.
Publicado: (2023)

The Synaptic Dysregulation in Adolescent Rats Exposed to Maternal Immune Activation
por: Cieślik, Magdalena, et al.
Publicado: (2021)

Developmental Stage-Dependent Changes in Mitochondrial Function in the Brain of Offspring Following Prenatal Maternal Immune Activation
por: Cieślik, Magdalena, et al.
Publicado: (2023)

Down-regulation of cyclin D2 in amyloid β toxicity, inflammation, and Alzheimer’s disease
por: Czapski, Grzegorz A., et al.
Publicado: (2021)

P2X7 Receptor is Involved in Mitochondrial Dysfunction Induced by Extracellular Alpha Synuclein in Neuroblastoma SH-SY5Y Cells
por: Wilkaniec, Anna, et al.
Publicado: (2020)

Synaptic Alterations in a Transgenic Model of Tuberous Sclerosis Complex: Relevance to Autism Spectrum Disorders
por: Czapski, Grzegorz A., et al.
Publicado: (2021)

Extracellular α-Synuclein Leads to Microtubule Destabilization via GSK-3β-Dependent Tau Phosphorylation in PC12 Cells
por: Gąssowska, Magdalena, et al.
Publicado: (2014)

Prenatal Exposure to Valproic Acid Affects Microglia and Synaptic Ultrastructure in a Brain-Region-Specific Manner in Young-Adult Male Rats: Relevance to Autism Spectrum Disorders
por: Gąssowska-Dobrowolska, Magdalena, et al.
Publicado: (2020)

Maternal Immune Activation Induces Neuroinflammation and Cortical Synaptic Deficits in the Adolescent Rat Offspring
por: Cieślik, Magdalena, et al.
Publicado: (2020)

The Molecular Mechanism of Amyloid β42 Peptide Toxicity: The Role of Sphingosine Kinase-1 and Mitochondrial Sirtuins
por: Cieślik, Magdalena, et al.
Publicado: (2015)

Sphingosine Kinases/Sphingosine-1-Phosphate and Death Signalling in APP-Transfected Cells
por: Gassowska, Magdalena, et al.
Publicado: (2014)

Alterations in Cerebellar Microtubule Cytoskeletal Network in a ValproicAcid-Induced Rat Model of Autism Spectrum Disorders
por: Gąssowska-Dobrowolska, Magdalena, et al.
Publicado: (2022)

Alterations in Tau Protein Level and Phosphorylation State in the Brain of the Autistic-Like Rats Induced by Prenatal Exposure to Valproic Acid
por: Gąssowska-Dobrowolska, Magdalena, et al.
Publicado: (2021)

Neuroinflammatory Cytokines Induce Amyloid Beta Neurotoxicity through Modulating Amyloid Precursor Protein Levels/Metabolism
por: Alasmari, Fawaz, et al.
Publicado: (2018)

Age-Related Transcriptional Deregulation of Genes Coding Synaptic Proteins in Alzheimer's Disease Murine Model: Potential Neuroprotective Effect of Fingolimod
por: Jęśko, Henryk, et al.
Publicado: (2021)

Alterations of Transcription of Genes Coding Anti-oxidative and Mitochondria-Related Proteins in Amyloid β Toxicity: Relevance to Alzheimer’s Disease
por: Cieślik, Magdalena, et al.
Publicado: (2019)

The novel amyloid-beta peptide aptamer inhibits intracellular amyloid-beta peptide toxicity
por: Wang, Xu, et al.
Publicado: (2013)

Alterations of Purinergic Receptors Levels and Their Involvement in the Glial Cell Morphology in a Pre-Clinical Model of Autism Spectrum Disorders
por: Babiec, Lidia, et al.
Publicado: (2023)

Selenium in the Therapy of Neurological Diseases. Where is it Going?
por: Dominiak, Agnieszka, et al.
Publicado: (2016)

Hybrid Amyloid Quantum Dot Nanoassemblies to Probe Neuroinflammatory Damage
por: Chiang, Wesley, et al.
Publicado: (2023)

Protective Effects of Selol Against Sodium Nitroprusside-Induced Cell Death and Oxidative Stress in PC12 Cells
por: Dominiak, Agnieszka, et al.
Publicado: (2016)

Glia-Neurotrophic Factor Relationships: Possible Role in Pathobiology of Neuroinflammation-Related Brain Disorders
por: Palasz, Ewelina, et al.
Publicado: (2023)

Oxidation destabilizes toxic amyloid beta peptide aggregation
por: Razzokov, J., et al.
Publicado: (2019)

Tyramine and Amyloid Beta 42: A Toxic Synergy
por: Dhakal, Sudip, et al.
Publicado: (2020)

Differential Effects of Endocannabinoids on Amyloid-Beta Aggregation and Toxicity
por: Khavandi, Marzie, et al.
Publicado: (2023)

Methyl Salicylate Lactoside Protects Neurons Ameliorating Cognitive Disorder Through Inhibiting Amyloid Beta-Induced Neuroinflammatory Response in Alzheimer’s Disease
por: Li, Jinze, et al.
Publicado: (2018)

Cyclin-Dependent Kinase-Like Function Is Shared by the Beta- and Gamma- Subset of the Conserved Herpesvirus Protein Kinases
por: Kuny, Chad V., et al.
Publicado: (2010)

Marine-derived protein kinase inhibitors for neuroinflammatory diseases
por: Ning, Chong, et al.
Publicado: (2018)

A Toxic Synergy between Aluminium and Amyloid Beta in Yeast
por: Mcdonald, Jamieson B., et al.
Publicado: (2021)

Cyclin-dependent kinases
por: Malumbres, Marcos
Publicado: (2014)

Beta-Secretase 1 Recruits Amyloid-Beta Precursor Protein to ROCK2 Kinase, Resulting in Erroneous Phosphorylation and Beta-Amyloid Plaque Formation
por: Hajdú, István, et al.
Publicado: (2023)

Perineuronal Nets and Their Role in Synaptic Homeostasis
por: Bosiacki, Mateusz, et al.
Publicado: (2019)

Exogenous Alpha-Synuclein Evoked Parkin Downregulation Promotes Mitochondrial Dysfunction in Neuronal Cells. Implications for Parkinson’s Disease Pathology
por: Wilkaniec, Anna, et al.
Publicado: (2021)

The Protective Role of Carnosic Acid against Beta-Amyloid Toxicity in Rats
por: Rasoolijazi, H., et al.
Publicado: (2013)

Amyloid Beta: Multiple Mechanisms of Toxicity and Only Some Protective Effects?
por: Carrillo-Mora, Paul, et al.
Publicado: (2014)

Atomic resolution map of the soluble amyloid beta assembly toxic surfaces
por: Ahmed, Rashik, et al.
Publicado: (2019)

Toxicities of amyloid-beta and tau protein are reciprocally enhanced in the Drosophila model
por: Sun, Zhen-Dong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8gqrcq9cb89sbalba1hd7dsbks