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Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts
AIM: Alcohol consumption during pregnancy is sometimes associated with adverse outcomes in offspring, potentially mediated by epigenetic modifications. We aimed to investigate genome-wide DNA methylation in cord blood of newborns exposed to alcohol in utero. MATERIALS & METHODS: We meta-analyzed...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Medicine Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753623/ https://www.ncbi.nlm.nih.gov/pubmed/29172695 http://dx.doi.org/10.2217/epi-2017-0095 |
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author | Sharp, Gemma C Arathimos, Ryan Reese, Sarah E Page, Christian M Felix, Janine Küpers, Leanne K Rifas-Shiman, Sheryl L Liu, Chunyu Burrows, Kimberley Zhao, Shanshan Magnus, Maria C Duijts, Liesbeth Corpeleijn, Eva DeMeo, Dawn L Litonjua, Augusto Baccarelli, Andrea Hivert, Marie-France Oken, Emily Snieder, Harold Jaddoe, Vincent Nystad, Wenche London, Stephanie J Relton, Caroline L Zuccolo, Luisa |
author_facet | Sharp, Gemma C Arathimos, Ryan Reese, Sarah E Page, Christian M Felix, Janine Küpers, Leanne K Rifas-Shiman, Sheryl L Liu, Chunyu Burrows, Kimberley Zhao, Shanshan Magnus, Maria C Duijts, Liesbeth Corpeleijn, Eva DeMeo, Dawn L Litonjua, Augusto Baccarelli, Andrea Hivert, Marie-France Oken, Emily Snieder, Harold Jaddoe, Vincent Nystad, Wenche London, Stephanie J Relton, Caroline L Zuccolo, Luisa |
author_sort | Sharp, Gemma C |
collection | PubMed |
description | AIM: Alcohol consumption during pregnancy is sometimes associated with adverse outcomes in offspring, potentially mediated by epigenetic modifications. We aimed to investigate genome-wide DNA methylation in cord blood of newborns exposed to alcohol in utero. MATERIALS & METHODS: We meta-analyzed information from six population-based birth cohorts within the Pregnancy and Childhood Epigenetics consortium. RESULTS: We found no strong evidence of association at either individual CpGs or across larger regions of the genome. CONCLUSION: Our findings suggest no association between maternal alcohol consumption and offspring cord blood DNA methylation. This is in stark contrast to the multiple strong associations previous studies have found for maternal smoking, which is similarly socially patterned. However, it is possible that a combination of a larger sample size, higher doses, different timings of exposure, exploration of a different tissue and a more global assessment of genomic DNA methylation might show evidence of association. |
format | Online Article Text |
id | pubmed-5753623 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Future Medicine Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-57536232018-01-22 Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts Sharp, Gemma C Arathimos, Ryan Reese, Sarah E Page, Christian M Felix, Janine Küpers, Leanne K Rifas-Shiman, Sheryl L Liu, Chunyu Burrows, Kimberley Zhao, Shanshan Magnus, Maria C Duijts, Liesbeth Corpeleijn, Eva DeMeo, Dawn L Litonjua, Augusto Baccarelli, Andrea Hivert, Marie-France Oken, Emily Snieder, Harold Jaddoe, Vincent Nystad, Wenche London, Stephanie J Relton, Caroline L Zuccolo, Luisa Epigenomics Research Article AIM: Alcohol consumption during pregnancy is sometimes associated with adverse outcomes in offspring, potentially mediated by epigenetic modifications. We aimed to investigate genome-wide DNA methylation in cord blood of newborns exposed to alcohol in utero. MATERIALS & METHODS: We meta-analyzed information from six population-based birth cohorts within the Pregnancy and Childhood Epigenetics consortium. RESULTS: We found no strong evidence of association at either individual CpGs or across larger regions of the genome. CONCLUSION: Our findings suggest no association between maternal alcohol consumption and offspring cord blood DNA methylation. This is in stark contrast to the multiple strong associations previous studies have found for maternal smoking, which is similarly socially patterned. However, it is possible that a combination of a larger sample size, higher doses, different timings of exposure, exploration of a different tissue and a more global assessment of genomic DNA methylation might show evidence of association. Future Medicine Ltd 2018-01 2017-11-27 /pmc/articles/PMC5753623/ /pubmed/29172695 http://dx.doi.org/10.2217/epi-2017-0095 Text en © 2018 Ryan Arathimos This work is licensed under the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Research Article Sharp, Gemma C Arathimos, Ryan Reese, Sarah E Page, Christian M Felix, Janine Küpers, Leanne K Rifas-Shiman, Sheryl L Liu, Chunyu Burrows, Kimberley Zhao, Shanshan Magnus, Maria C Duijts, Liesbeth Corpeleijn, Eva DeMeo, Dawn L Litonjua, Augusto Baccarelli, Andrea Hivert, Marie-France Oken, Emily Snieder, Harold Jaddoe, Vincent Nystad, Wenche London, Stephanie J Relton, Caroline L Zuccolo, Luisa Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts |
title | Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts |
title_full | Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts |
title_fullStr | Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts |
title_full_unstemmed | Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts |
title_short | Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts |
title_sort | maternal alcohol consumption and offspring dna methylation: findings from six general population-based birth cohorts |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753623/ https://www.ncbi.nlm.nih.gov/pubmed/29172695 http://dx.doi.org/10.2217/epi-2017-0095 |
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