Cargando…

Investigation of Polyamine Metabolism and Homeostasis in Pancreatic Cancers

Pancreatic cancers are currently the fourth leading cause of cancer-related death and new therapies are desperately needed. The most common pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC). This report describes the development of therapies, which effectively deplete PDAC cells of their...

Descripción completa

Detalles Bibliográficos
Autores principales:	Massaro, Chelsea, Thomas, Jenna, Phanstiel, Otto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753661/ https://www.ncbi.nlm.nih.gov/pubmed/29215586 http://dx.doi.org/10.3390/medsci5040032

Ejemplares similares

ATP13A3 facilitates polyamine transport in human pancreatic cancer cells
por: Sekhar, Vandana, et al.
Publicado: (2022)

Polyamine-Based Nanostructures Share Polyamine Transport Mechanisms with Native Polyamines and Their Analogues: Significance for Polyamine-Targeted Therapy
por: Holbert, Cassandra E., et al.
Publicado: (2022)

Differential Expression of Polyamine Pathways in Human Pancreatic Tumor Progression and Effects of Polyamine Blockade on Tumor Microenvironment
por: Nakkina, Sai Preethi, et al.
Publicado: (2021)

A Novel Polyamine-Targeted Therapy for BRAF Mutant Melanoma Tumors
por: Peters, Molly C., et al.
Publicado: (2018)

Evaluation of Polyamine Transport Inhibitors in a Drosophila Epithelial Model Suggests the Existence of Multiple Transport Systems
por: Wang, Minpei, et al.
Publicado: (2017)

Loss of Anti-Tumor Efficacy by Polyamine Blocking Therapy in GCN2 Null Mice
por: Alexander, Eric T., et al.
Publicado: (2023)

A novel polyamine blockade therapy activates an anti-tumor immune response
por: Alexander, Eric T., et al.
Publicado: (2017)

Uptake of Biotinylated Spermine in Astrocytes: Effect of Cx43 siRNA, HIV-Tat Protein and Polyamine Transport Inhibitor on Polyamine Uptake
por: Malpica-Nieves, Christian J., et al.
Publicado: (2021)

Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing
por: Reigada, Chantal, et al.
Publicado: (2019)

Elucidating the Role of Chmp1 Overexpression in the Transport of Polyamines in Drosophila melanogaster
por: Stump, Coryn L., et al.
Publicado: (2022)

Polyamine Homeostasis in Development and Disease
por: Nakanishi, Shima, et al.
Publicado: (2021)

Genetic portrait of polyamine transporters in barley: insights in the regulation of leaf senescence
por: Stolarska, Ewelina, et al.
Publicado: (2023)

Polyamines and Their Metabolism: From the Maintenance of Physiological Homeostasis to the Mediation of Disease
por: Zahedi, Kamyar, et al.
Publicado: (2022)

Polyamine Homeostasis in Snyder-Robinson Syndrome
por: Murray-Stewart, Tracy, et al.
Publicado: (2018)

Elevated Polyamines in Saliva of Pancreatic Cancer
por: Asai, Yasutsugu, et al.
Publicado: (2018)

Polyamine Homeostasis in Wild Type and Phenolamide Deficient Arabidopsis thaliana Stamens
por: Fellenberg, Christin, et al.
Publicado: (2012)

Cation Homeostasis: Coordinate Regulation of Polyamine and Magnesium Levels in Salmonella
por: Iwadate, Yumi, et al.
Publicado: (2022)

Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies
por: Murray-Stewart, Tracy, et al.
Publicado: (2018)

Polyamines and polyamine-metabolizing enzymes in schizophrenia: Current knowledge and concepts of therapy
por: Bernstein, Hans-Gert, et al.
Publicado: (2021)

Responses of Polyamine-Metabolic Genes to Polyamines and Plant Stress Hormones in Arabidopsis Seedlings
por: Yariuchi, Yusaku, et al.
Publicado: (2021)

tpo3 and dur3, Aspergillus fumigatus Plasma Membrane Regulators of Polyamines, Regulate Polyamine Homeostasis and Susceptibility to Itraconazole
por: Chen, Mingcong, et al.
Publicado: (2020)

Stress and polyamine metabolism in fungi
por: Valdés-Santiago, Laura, et al.
Publicado: (2014)

Polyamine Metabolism Changes in Psoriasis
por: Broshtilova, Valentina, et al.
Publicado: (2013)

Polyamines Are Present in Mast Cell Secretory Granules and Are Important for Granule Homeostasis
por: García-Faroldi, Gianni, et al.
Publicado: (2010)

Modulating the polyamine/hypusine axis controls generation of CD8(+) tissue-resident memory T cells
por: Elmarsafawi, Aya G., et al.
Publicado: (2023)

Discrimination between Pancreatic Cancer, Pancreatitis and Healthy Controls Using Urinary Polyamine Panel
por: Nissinen, Samuli I., et al.
Publicado: (2022)

Expanded Potential of the Polyamine Analogue SBP-101 (Diethyl Dihydroxyhomospermine) as a Modulator of Polyamine Metabolism and Cancer Therapeutic
por: Holbert, Cassandra E., et al.
Publicado: (2022)

Unmasking metabolic dependencies in pancreatic cancer: aberrant polyamine synthesis as a promising new therapeutic target
por: Wolters-Eisfeld, Gerrit, et al.
Publicado: (2023)

Regulation of Polyamine Metabolism by Curcumin for Cancer Prevention and Therapy
por: Murray-Stewart, Tracy, et al.
Publicado: (2017)

One-Carbon and Polyamine Metabolism as Cancer Therapy Targets
por: Islam, Anowarul, et al.
Publicado: (2022)

Correlation of polyamines, acrolein-conjugated lysine and polyamine metabolic enzyme levels with age in human liver
por: Uemura, Takeshi, et al.
Publicado: (2020)

Investigation of Naphthyl–Polyamine Conjugates as Antimicrobials and Antibiotic Enhancers
por: Cadelis, Melissa M., et al.
Publicado: (2023)

Editorial to the Special Issue on “Polyamine Metabolism in Health and Disease: Potential for Polyamine-Targeted Therapies and Prevention”
por: Stewart, Tracy Murray
Publicado: (2023)

Polyamine Metabolism in Fungi with Emphasis on Phytopathogenic Species
por: Valdés-Santiago, Laura, et al.
Publicado: (2012)

β-N-Methylamino-L-Alanine (BMAA) Modulates the Sympathetic Regulation and Homeostasis of Polyamines
por: Shkodrova, Milena, et al.
Publicado: (2023)

Persistent Coxsackievirus B3 Infection in Pancreatic Ductal Cells In Vitro Downregulates Cellular Polyamine Metabolism
por: Mastrodomenico, Vincent, et al.
Publicado: (2023)

Practical Synthesis of Polyamine Succinamides and Branched Polyamines
por: Alkhzem, Abdulaziz H., et al.
Publicado: (2022)

Histone deacetylase-10 liberates spermidine to support polyamine homeostasis and tumor cell growth
por: Stewart, Tracy Murray, et al.
Publicado: (2022)

Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C-Methylated Spermine Derivatives
por: Khomutov, Maxim, et al.
Publicado: (2019)

Investigation of Indolglyoxamide and Indolacetamide Analogues of Polyamines as Antimalarial and Antitrypanosomal Agents
por: Wang, Jiayi, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_e8cacn1j455egomke7t8g0d5r6