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The Clinical Characteristics and Prognosis of Crohn’s Disease in Korean Patients Showing Proximal Small Bowel Involvement: Results from the CONNECT Study

BACKGROUND/AIMS: We aimed to evaluate the clinical characteristics and prognosis of Crohn’s disease (CD) in patients who showed proximal small bowel involvement using a nationwide Korean CD cohort. METHODS: We reviewed the data from a cohort of patients diagnosed with CD. The clinical outcomes of pa...

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Autores principales: Kim, One Zoong, Han, Dong Soo, Park, Chan Hyuk, Eun, Chang Soo, Kim, You Sun, Kim, Young-Ho, Cheon, Jae Hee, Ye, Byong Duk, Kim, Joo Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Office of Gut and Liver 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753686/
https://www.ncbi.nlm.nih.gov/pubmed/28798284
http://dx.doi.org/10.5009/gnl16500
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author Kim, One Zoong
Han, Dong Soo
Park, Chan Hyuk
Eun, Chang Soo
Kim, You Sun
Kim, Young-Ho
Cheon, Jae Hee
Ye, Byong Duk
Kim, Joo Sung
author_facet Kim, One Zoong
Han, Dong Soo
Park, Chan Hyuk
Eun, Chang Soo
Kim, You Sun
Kim, Young-Ho
Cheon, Jae Hee
Ye, Byong Duk
Kim, Joo Sung
author_sort Kim, One Zoong
collection PubMed
description BACKGROUND/AIMS: We aimed to evaluate the clinical characteristics and prognosis of Crohn’s disease (CD) in patients who showed proximal small bowel involvement using a nationwide Korean CD cohort. METHODS: We reviewed the data from a cohort of patients diagnosed with CD. The clinical outcomes of patients were evaluated according to the presence of proximal small bowel involvement. RESULTS: Among 1,329 patients with CD for whom complete disease location data were available, 222 patients (16.7%) showed involvement of the proximal small bowel. Compared to patients without proximal small bowel involvement, those with small bowel involvement were more likely to display stricturing behavior (19.8% vs 12.7%, p=0.020). The surgery-free survival of patients who showed proximal small bowel involvement was inferior to that of patients without proximal small bowel involvement (10-year surgery-free survival: 58.4% vs 67.7%, respectively, p<0.001). Additionally, upper gastrointestinal involvement was more common in patients with proximal small bowel involvement than in those without involvement (odds ratio, 1.643; 95% confidence interval, 1.008 to 2.677). CONCLUSIONS: Proximal small bowel involvement is a poor prognostic factor for the surgery-free survival of Korean patients with CD. Proximal small bowel involvement should be evaluated in patients with CD for predicting long-term clinical outcomes.
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spelling pubmed-57536862018-01-19 The Clinical Characteristics and Prognosis of Crohn’s Disease in Korean Patients Showing Proximal Small Bowel Involvement: Results from the CONNECT Study Kim, One Zoong Han, Dong Soo Park, Chan Hyuk Eun, Chang Soo Kim, You Sun Kim, Young-Ho Cheon, Jae Hee Ye, Byong Duk Kim, Joo Sung Gut Liver Original Article BACKGROUND/AIMS: We aimed to evaluate the clinical characteristics and prognosis of Crohn’s disease (CD) in patients who showed proximal small bowel involvement using a nationwide Korean CD cohort. METHODS: We reviewed the data from a cohort of patients diagnosed with CD. The clinical outcomes of patients were evaluated according to the presence of proximal small bowel involvement. RESULTS: Among 1,329 patients with CD for whom complete disease location data were available, 222 patients (16.7%) showed involvement of the proximal small bowel. Compared to patients without proximal small bowel involvement, those with small bowel involvement were more likely to display stricturing behavior (19.8% vs 12.7%, p=0.020). The surgery-free survival of patients who showed proximal small bowel involvement was inferior to that of patients without proximal small bowel involvement (10-year surgery-free survival: 58.4% vs 67.7%, respectively, p<0.001). Additionally, upper gastrointestinal involvement was more common in patients with proximal small bowel involvement than in those without involvement (odds ratio, 1.643; 95% confidence interval, 1.008 to 2.677). CONCLUSIONS: Proximal small bowel involvement is a poor prognostic factor for the surgery-free survival of Korean patients with CD. Proximal small bowel involvement should be evaluated in patients with CD for predicting long-term clinical outcomes. Editorial Office of Gut and Liver 2018-01 2017-08-14 /pmc/articles/PMC5753686/ /pubmed/28798284 http://dx.doi.org/10.5009/gnl16500 Text en Copyright © 2018 by The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, One Zoong
Han, Dong Soo
Park, Chan Hyuk
Eun, Chang Soo
Kim, You Sun
Kim, Young-Ho
Cheon, Jae Hee
Ye, Byong Duk
Kim, Joo Sung
The Clinical Characteristics and Prognosis of Crohn’s Disease in Korean Patients Showing Proximal Small Bowel Involvement: Results from the CONNECT Study
title The Clinical Characteristics and Prognosis of Crohn’s Disease in Korean Patients Showing Proximal Small Bowel Involvement: Results from the CONNECT Study
title_full The Clinical Characteristics and Prognosis of Crohn’s Disease in Korean Patients Showing Proximal Small Bowel Involvement: Results from the CONNECT Study
title_fullStr The Clinical Characteristics and Prognosis of Crohn’s Disease in Korean Patients Showing Proximal Small Bowel Involvement: Results from the CONNECT Study
title_full_unstemmed The Clinical Characteristics and Prognosis of Crohn’s Disease in Korean Patients Showing Proximal Small Bowel Involvement: Results from the CONNECT Study
title_short The Clinical Characteristics and Prognosis of Crohn’s Disease in Korean Patients Showing Proximal Small Bowel Involvement: Results from the CONNECT Study
title_sort clinical characteristics and prognosis of crohn’s disease in korean patients showing proximal small bowel involvement: results from the connect study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753686/
https://www.ncbi.nlm.nih.gov/pubmed/28798284
http://dx.doi.org/10.5009/gnl16500
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