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New stereolithographic resin providing functional surfaces for biocompatible three-dimensional printing

Stereolithography is one of the most promising technologies for the production of tailored implants. Within this study, we show the results of a new resin formulation for three-dimensional printing which is also useful for subsequent surface functionalization. The class of materials is based on mono...

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Autores principales: Hoffmann, Andreas, Leonards, Holger, Tobies, Nora, Pongratz, Ludwig, Kreuels, Klaus, Kreimendahl, Franziska, Apel, Christian, Wehner, Martin, Nottrodt, Nadine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753888/
https://www.ncbi.nlm.nih.gov/pubmed/29318001
http://dx.doi.org/10.1177/2041731417744485
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author Hoffmann, Andreas
Leonards, Holger
Tobies, Nora
Pongratz, Ludwig
Kreuels, Klaus
Kreimendahl, Franziska
Apel, Christian
Wehner, Martin
Nottrodt, Nadine
author_facet Hoffmann, Andreas
Leonards, Holger
Tobies, Nora
Pongratz, Ludwig
Kreuels, Klaus
Kreimendahl, Franziska
Apel, Christian
Wehner, Martin
Nottrodt, Nadine
author_sort Hoffmann, Andreas
collection PubMed
description Stereolithography is one of the most promising technologies for the production of tailored implants. Within this study, we show the results of a new resin formulation for three-dimensional printing which is also useful for subsequent surface functionalization. The class of materials is based on monomers containing either thiol or alkene groups. By irradiation of the monomers at a wavelength of 266 nm, we demonstrated an initiator-free stereolithographic process based on thiol-ene click chemistry. Specimens made from this material have successfully been tested for biocompatibility. Using Fourier-transform infrared spectrometry and fluorescent staining, we are able to show that off-stoichiometric amounts of functional groups in the monomers allow us to produce scaffolds with functional surfaces. We established a new protocol to demonstrate the opportunity to functionalize the surface by copper-catalyzed azide-alkyne cycloaddition chemistry. Finally, we demonstrate a three-dimensional bioprinting concept for the production of potentially biocompatible polymers with thiol-functionalized surfaces usable for subsequent functionalization.
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spelling pubmed-57538882018-01-09 New stereolithographic resin providing functional surfaces for biocompatible three-dimensional printing Hoffmann, Andreas Leonards, Holger Tobies, Nora Pongratz, Ludwig Kreuels, Klaus Kreimendahl, Franziska Apel, Christian Wehner, Martin Nottrodt, Nadine J Tissue Eng Design and Manufacture of Tissue Engineered Products using Additive Manufacturing Techniques Stereolithography is one of the most promising technologies for the production of tailored implants. Within this study, we show the results of a new resin formulation for three-dimensional printing which is also useful for subsequent surface functionalization. The class of materials is based on monomers containing either thiol or alkene groups. By irradiation of the monomers at a wavelength of 266 nm, we demonstrated an initiator-free stereolithographic process based on thiol-ene click chemistry. Specimens made from this material have successfully been tested for biocompatibility. Using Fourier-transform infrared spectrometry and fluorescent staining, we are able to show that off-stoichiometric amounts of functional groups in the monomers allow us to produce scaffolds with functional surfaces. We established a new protocol to demonstrate the opportunity to functionalize the surface by copper-catalyzed azide-alkyne cycloaddition chemistry. Finally, we demonstrate a three-dimensional bioprinting concept for the production of potentially biocompatible polymers with thiol-functionalized surfaces usable for subsequent functionalization. SAGE Publications 2017-12-21 /pmc/articles/PMC5753888/ /pubmed/29318001 http://dx.doi.org/10.1177/2041731417744485 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Design and Manufacture of Tissue Engineered Products using Additive Manufacturing Techniques
Hoffmann, Andreas
Leonards, Holger
Tobies, Nora
Pongratz, Ludwig
Kreuels, Klaus
Kreimendahl, Franziska
Apel, Christian
Wehner, Martin
Nottrodt, Nadine
New stereolithographic resin providing functional surfaces for biocompatible three-dimensional printing
title New stereolithographic resin providing functional surfaces for biocompatible three-dimensional printing
title_full New stereolithographic resin providing functional surfaces for biocompatible three-dimensional printing
title_fullStr New stereolithographic resin providing functional surfaces for biocompatible three-dimensional printing
title_full_unstemmed New stereolithographic resin providing functional surfaces for biocompatible three-dimensional printing
title_short New stereolithographic resin providing functional surfaces for biocompatible three-dimensional printing
title_sort new stereolithographic resin providing functional surfaces for biocompatible three-dimensional printing
topic Design and Manufacture of Tissue Engineered Products using Additive Manufacturing Techniques
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753888/
https://www.ncbi.nlm.nih.gov/pubmed/29318001
http://dx.doi.org/10.1177/2041731417744485
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