Riociguat, a soluble guanylate cyclase stimulator, ameliorates right ventricular contraction in pulmonary arterial hypertension

Riociguat is a soluble guanylate cyclase stimulator used for pulmonary hypertension (PH) treatment. We evaluated right ventricular (RV) contractile function in 27 PH patients receiving riociguat. A comparison of pre- and post-administration echocardiographic studies demonstrated significantly improv...

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Detalles Bibliográficos
Autores principales: Murata, Mitsushige, Kawakami, Takashi, Kataoka, Masaharu, Kohno, Takashi, Itabashi, Yuji, Fukuda, Keiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753926/
https://www.ncbi.nlm.nih.gov/pubmed/29251547
http://dx.doi.org/10.1177/2045893217746111
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author Murata, Mitsushige
Kawakami, Takashi
Kataoka, Masaharu
Kohno, Takashi
Itabashi, Yuji
Fukuda, Keiichi
author_facet Murata, Mitsushige
Kawakami, Takashi
Kataoka, Masaharu
Kohno, Takashi
Itabashi, Yuji
Fukuda, Keiichi
author_sort Murata, Mitsushige
collection PubMed
description Riociguat is a soluble guanylate cyclase stimulator used for pulmonary hypertension (PH) treatment. We evaluated right ventricular (RV) contractile function in 27 PH patients receiving riociguat. A comparison of pre- and post-administration echocardiographic studies demonstrated significantly improved RV strain after riociguat treatment, even after adjusting for RV afterload.
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spelling pubmed-57539262018-01-09 Riociguat, a soluble guanylate cyclase stimulator, ameliorates right ventricular contraction in pulmonary arterial hypertension Murata, Mitsushige Kawakami, Takashi Kataoka, Masaharu Kohno, Takashi Itabashi, Yuji Fukuda, Keiichi Pulm Circ Research Letter Riociguat is a soluble guanylate cyclase stimulator used for pulmonary hypertension (PH) treatment. We evaluated right ventricular (RV) contractile function in 27 PH patients receiving riociguat. A comparison of pre- and post-administration echocardiographic studies demonstrated significantly improved RV strain after riociguat treatment, even after adjusting for RV afterload. SAGE Publications 2017-12-18 /pmc/articles/PMC5753926/ /pubmed/29251547 http://dx.doi.org/10.1177/2045893217746111 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by/4.0/ Creative Commons CC-BY: This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Letter
Murata, Mitsushige
Kawakami, Takashi
Kataoka, Masaharu
Kohno, Takashi
Itabashi, Yuji
Fukuda, Keiichi
Riociguat, a soluble guanylate cyclase stimulator, ameliorates right ventricular contraction in pulmonary arterial hypertension
title Riociguat, a soluble guanylate cyclase stimulator, ameliorates right ventricular contraction in pulmonary arterial hypertension
title_full Riociguat, a soluble guanylate cyclase stimulator, ameliorates right ventricular contraction in pulmonary arterial hypertension
title_fullStr Riociguat, a soluble guanylate cyclase stimulator, ameliorates right ventricular contraction in pulmonary arterial hypertension
title_full_unstemmed Riociguat, a soluble guanylate cyclase stimulator, ameliorates right ventricular contraction in pulmonary arterial hypertension
title_short Riociguat, a soluble guanylate cyclase stimulator, ameliorates right ventricular contraction in pulmonary arterial hypertension
title_sort riociguat, a soluble guanylate cyclase stimulator, ameliorates right ventricular contraction in pulmonary arterial hypertension
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753926/
https://www.ncbi.nlm.nih.gov/pubmed/29251547
http://dx.doi.org/10.1177/2045893217746111
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